Biomedical EngineeringBiyomedikal Mühendisliğihttps://hdl.handle.net/20.500.12511/41602024-03-28T15:41:56Z2024-03-28T15:41:56ZOptimizing percutaneous pulmonary valve implantation with patient-specific 3D-printed pulmonary artery models and hemodynamic assessmentÖdemiş, EnderAka, İbrahim BaşarAli, Mhd Homam AlhajGümüş, TermanPekkan, Keremhttps://hdl.handle.net/20.500.12511/122592024-02-09T11:25:05Z2024-01-01T00:00:00ZOptimizing percutaneous pulmonary valve implantation with patient-specific 3D-printed pulmonary artery models and hemodynamic assessment
Ödemiş, Ender; Aka, İbrahim Başar; Ali, Mhd Homam Alhaj; Gümüş, Terman; Pekkan, Kerem
Background: Percutaneous pulmonary valve implantation (PPVI) has emerged as a less invasive alternative for treating severe pulmonary regurgitation after tetralogy of Fallot (TOF) repair in patients with a native right ventricular outflow tract (RVOT). However, the success of PPVI depends on precise patient-specific valve sizing, the avoidance of oversizing complications, and optimal valve performance. In recent years, innovative adaptations of commercially available cardiovascular mock loops have been used to test conduits in the pulmonary position. These models are instrumental in facilitating accurate pulmonic valve sizing, mitigating the risk of oversizing, and providing insight into the valve performance before implantation. This study explored the utilization of custom-modified mock loops to implant patient-specific 3D-printed pulmonary artery geometries, thereby advancing PPVI planning and execution.Material and Methods: Patient-specific 3D-printed pulmonary artery geometries of five patients who underwent PPVI using Pulsta transcatheter heart valve (THV) (R) were tested in a modified ViVitro pulse duplicator system (R). Various valve sizes were subjected to 10 cycles of testing at different cardiac output levels. The transpulmonary systolic and regurgitation fractions of the valves were also recorded and compared.Results: A total of 39 experiments were conducted using five different patient geometries and several different valve sizes (26, 28, 30, and 32 mm) at 3, 4, and 5 L/min cardiac output at heart rates of 70 beats per minute (bpm) and 60/40 systolic/diastolic ratios. The pressure gradients and regurgitation fractions of the tested valve sizes in the models were found to be similar to the pressure gradients and regurgitation fractions of valves used in real procedures. However, in two patients, different valve sizes showed better hemodynamic values than the actual implanted valves.Discussion: The use of 3D printing technology, electromagnetic flow meters, and the custom-modified ViVitro pulse duplicator system (R) in conjunction with patient-specific pulmonary artery models has enabled a comprehensive assessment of percutaneous pulmonic valve implantation performance. This approach allows for accurate valve sizing, minimization of oversizing risks, and valuable insights into hemodynamic behavior before implantation. The data obtained from this experimental setup will contribute to advancing PPVI procedures and offer potential benefits in improving patient outcomes and safety.
2024-01-01T00:00:00ZSurgical and transcatheter pulmonary valve replacement in patients with repaired tetralogy of Fallot: Cardiac magnetic resonance imaging characteristics and morphology of right ventricular outflow tractÖzkök, SerçinÇiftçi, Hatice ÖzgeKöse, Kevser BanuYücel, İlker KemalŞaşmazel, AhmetÇelebi, AhmetPekkan, Keremhttps://hdl.handle.net/20.500.12511/122372024-02-01T13:04:11Z2023-01-01T00:00:00ZSurgical and transcatheter pulmonary valve replacement in patients with repaired tetralogy of Fallot: Cardiac magnetic resonance imaging characteristics and morphology of right ventricular outflow tract
Özkök, Serçin; Çiftçi, Hatice Özge; Köse, Kevser Banu; Yücel, İlker Kemal; Şaşmazel, Ahmet; Çelebi, Ahmet; Pekkan, Kerem
BackgroundPulmonary valve replacement is recommended in patients with repaired tetralogy of Fallot based on cardiac magnetic resonance imaging (MRI) criteria. This procedure is performed by surgical or transcatheter approaches.ObjectiveWe aimed to investigate the differences in preprocedural MRI characteristics (volume, function, strain) and morphology of the right ventricular outflow tract and branch pulmonary arteries in patients for whom surgical or transcatheter pulmonary valve replacement was planned.Materials and methodsCardiac MRI of 166 patients with tetralogy of Fallot were analyzed. Of these, 36 patients for whom pulmonary valve replacement was planned were included. Magnetic resonance imaging characteristics, right ventricular outflow tract morphology, branch pulmonary artery flow distribution and diameter were compared between surgical and transcatheter groups. Spearman correlation and Kruskal-Wallis tests were performed.ResultsCircumferential and radial MRI strain for the right ventricle were lower in the surgical group (P=0.045 and P=0.046, respectively). The diameter of the left pulmonary artery was significantly lower (P=0.021) and branch pulmonary artery flow and diameter ratio were higher (P=0.044 and P = 0.002, respectively) in the transcatheter group. There was a significant correlation between right ventricular outflow tract morphology and right ventricular end-diastolic volume index and global circumferential and radial MRI strain (P=0.046, P=0.046 and P= 0.049, respectively).ConclusionPreprocedural MRI strain, right-to-left pulmonary artery flow, diameter ratio and morphological features of the right ventricular outflow tract were significantly different between the two groups. A transcatheter approach may be recommended for patients with branch pulmonary artery stenosis, since both pulmonary valve replacement and branch pulmonary artery stenting can be performed in the same session.
2023-01-01T00:00:00ZIonic liquid based treatment - A potential strategy to modify bacterial celluloseMunir, MuneebaMuhammad, NawshadUroos, MalihaMustafa, WaleedSharif, Faizahttps://hdl.handle.net/20.500.12511/121992024-01-25T10:24:46Z2023-01-01T00:00:00ZIonic liquid based treatment - A potential strategy to modify bacterial cellulose
Munir, Muneeba; Muhammad, Nawshad; Uroos, Maliha; Mustafa, Waleed; Sharif, Faiza
The constant need for advanced materials led by modern research continues the exploitation of old remedies and innovation to find new solutions. The use of ionic liquids (ILs) as solvents has revolutionized modern chemical research. The non-toxic green technology has inspired new paradigms in chemical reactions and synthesis. Developing nontoxic materials for industrial and biomedical applications has endorsed the use of ILs in synthesis and fabrication. In terms of biomedical materials, the exploration for novel technologies to deal with chronic and nonhealing injuries desires degradable materials. One of the vastly used biomaterials is cellulose, which is nondegradable on its own unless digested by special enzymes produced by bacteria in nature. Bacterial cellulose (BC) is a naturally occurring more refined and purified form of cellulose which again is nondegradable on its own. Looking for technologies that can modify the BC in situ or ex situ is a challenge. This review is bound to give insight into the current scientific research being conducted to render BC degradable for biomedical applications. The data has been collected through Clarivate analysis, Google search, PubMed Central Identifier (PMCID), and Research Gate. The lack of available literature on this topic allowed us to include all the articles related to the subject as old as 1988 onwards.
2023-01-01T00:00:00ZCentralized healthcare database for ensuring better healthcare: Are we lagging behind?Tariq, SundusTariq, SabaShoukat, Ahmad Adnanhttps://hdl.handle.net/20.500.12511/121442024-03-22T07:07:59Z2024-01-01T00:00:00ZCentralized healthcare database for ensuring better healthcare: Are we lagging behind?
Tariq, Sundus; Tariq, Saba; Shoukat, Ahmad Adnan
Database is an organized set of large information gathered and stored electronically to be retrieved whenever required. The systematically stored information can be accessed, analyzed, updated or moved to other databases as per the requirement. A centralized healthcare database (CHD) is a memory house of health data from a wider population, where information such as health records, financial data, billing and claims information and inventory use is not only stored systematically but can also be retrieved, analyzed, and integrated. The data can be assessed by the health care providers, researchers, policy makers, institutions and by the patients themselves.
2024-01-01T00:00:00Z