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Investigation of antimicrobial activities of some herbs containing essential oils and their mouthwash formulations
(Turkish Pharmacists Association, 2018)
Objectives: The aim of this study was to prepare pharmaceutical formulations of mouthwashes and to examine the antimicrobial activities of essential oils obtained from plants used traditionally in Turkey for oral infections. ...
The essential oils of two Achillea L. Species from Turkey
(İstanbul Medipol University, 2018)
Chemical composition of the essential oils obtained by hydrodistillation from the aerial parts of Achillea biebersteinii Afan. and A. wilhelmsii C. Koch were analyzed by GC-FID and GC-MS. The essential oils of A. biebersteinii ...
Comparison of 3 doses of aloe vera and burn drugs in market on burnt rat models
(İstanbul Medipol University, 2018)
Burn injuries are an incident that can have serious traumatic consequences. Degree of tissue damage depends on height of heat and duration of contact. It can be classified as 4 different burn degrees. Herbal treatments can ...
Novel benzothiazole based imidazole derivatives as new cytotoxic agents against glioma (C6) and liver (HepG2) cancer cell lines
(University of Istanbul, 2017)
In this work, some novel N-(6-substituted-benzothiazol-2-yl)-2-[[4,5-dimethyl-1-((p-tolyl/4-nitrophenyl)amino)-1H-imidazol-2-yl]thio]acetamide derivatives were synthesized and searched for their cytotoxic activities against ...
In vitro antimicrobial and antioxidant activity evaluation of melampyrum arvense L. Var. elatius boiss. and sedum spurium m. bieb. extracts
(İstanbul Medipol University, 2019)
Sedum spurium M. Bieb. (Crassulaceae) is a common ornamental plant, whereas, Melampyrum arvense L. var. elatius Boiss. (Orobanchaceae) is a semi-parasitic plant and grows naturally in the fields. In this study, the ...
Formulation of microemulsions for dermal delivery of Cephalexin
(University of Istanbul, 2017)
Introduction: Cephalexin monohydrate (CEM) is mostly used because of its activity against both the gram-positive and gram-negative microorganisms for infections. Microemulsions offer numerous advantages for dermal delivery ...
Development and validation of an HPLC method for voriconazole active substance in bulk and its pharmaceutical formulation
(Marmara University, 2016)
The aim of the present study was to develop and validate a High-Performance Liquid Chromatography (HPLC) method for the determination of voriconazole in drug substances and in situ gel. A mixture of acetonitrile and ultrapure ...
The effects of some imidazopyrazine derivatives on telomerase inhibition, mtDNA damage and mtDNA copy number
(University of Istanbul, 2017)
Imidazopyrazine derivatives have been studied for their curative effects on some diseases like cancer and neurological problems; also, some of these molecules have been patented. Primary human cells exhibit limited replicative ...
Antimicrobial activity evaluation of new 1,3,4-oxadiazole derivatives
(University of Istanbul, 2017)
In this study, we have synthesized seven novel 2-[(5-(4-chlorobenzyl)-1,3,4-oxadiazol-2-yl)thio]-N-(6-substituted benzothiazol-2-yl)acetamide derivatives (4ag) starting from ethyl 4-chlorophenyl acetate. The antimicrobial ...
A contraindication to metfromin therapy: Renal impairment - Adherence to prescribing guidelines at a hospital in Turkey
(University of Istanbul, 2018)
Objective: The aim of this study was to investigate whether renal functions of the patients were monitored and checked before and during metformin treatment as recommended in guidelines or whether they were disregarded and ...