Yazar "Ayla, Şule" için Makale Koleksiyonu listeleme
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An alternative approach to wound healing field; New composite films from natural polymers for Mupirocin dermal delivery
Okur, Neslihan Üstündağ; Hökenek, Nesrin; Okur, Mehmet Evren; Ayla, Şule; Yoltaş, Ayşegül; Siafaka, Panoraia I.; Cevher, Erdal (Elsevier, 2019)In this study, novel adhesive films were prepared for Mupirocin dermal delivery. Natural polymers as chitosan, sodium alginate and carbopol were used for films development to evaluate possible interactions and drug release ... -
An alternative approach wound healing field with polypodium vulgare
Batur, Şebnem; Ayla, Şule; Şakul, Ayşe Arzu; Okur, Mehmet Evren; Karadağ, Ayşe Esra; Daylan, Benay; Özdemir, Ekrem Musa; Kepil, Nuray; Günal, Mehmet Yalçın (Logos Medical Publishing, 2020)Objective: In this study, we examined the effects of Polypodium vulgare L. (Polypodiaceae) as a candidate to be used for wound healing scarred area. We investigated the antibacterial, and antioxidant activity of P. Vulgare ... -
Anti-inflammatory, analgesic and in vivo-in vitro wound healing potential of the Phlomis rigida Labill. extract
Okur, Mehmet Evren; Karadağ, Ayşe Esra; Özhan, Yağmur; Sipahi, Hande; Ayla, Şule; Daylan, Benay; Kültür, Şükran; Demirci, Betül; Demirci, Fatih (Elsevier Ireland Ltd, 2021)Ethnopharmacological relevance: The preparations of Phlomis aerial parts are used traditionally in Anatolia for wound healing and in inflammatory disorders. Methods: For the identification of the active fraction, the air ... -
Antioxidant activity of blackthorn (Prunus spinosa L.) fruit extract and cytotoxic effects on various cancer cell lines
Karakaş, Nihal; Okur, Mehmet Evren; Öztürk, İrem; Ayla, Şule; Karadağ, Ayşe Esra; Polat, Derya Çiçek (Logos Medical Publishing, 2019)Objective: Blackthorn (Prunus spinosa L. (Rosaceae) is a shrup whose fruits are consumed as food in Turkey. This study was aimed to evaluate antioxidant activity of methanol extract of P. spinosa and its cytotoxic effects ... -
Design and characterization of nanocarriers loaded with Levofloxacin for enhanced antimicrobial activity; Physicochemical properties, in vitro release and oral acute toxicity
Siafaka, Panoraia; Okur, Mehmet Evren; Ayla, Şule; Er, Sevda; Çağlar, Emre Şefik; Okur, Neslihan Üstündağ (Faculdade de Ciencias Farmaceuticas (Biblioteca), 2019)Inorganic and carbon based nanomaterials are widely used against several diseases, such as cancer, autoimmune diseases as well as fungi and bacteria colonization. In this work, Santa Barbara Amorphous mesoporous silica ... -
Evaluation of in situ gel containing pycnogenol for cutaneous wound healing
Okur, Mehmet Evren; Ayla, Şule; Batur, Şebnem; Yoltaş, Ayşegül; Genç, Ecem; Pertek, Sinem; Üstündağ Okur, Neslihan (Logos Medical Publishing, 2019)Aim: Pycnogenol® (PYC) are used for various medicinal purposes. The aims of the present study were toevaluate wound healing activity of PYC loaded in situ gel in mice and to investigate its antibacterial activity.Method: ... -
In vivo wound healing and in vitro anti-inflammatory activity evaluation of phlomis russeliana extract gel formulations
Okur, Mehmet Evren; Karadağ, Ayşe Esra; Üstündağ Okur, Neslihan; Özhan, Yağmur; Sipahi, Hande; Ayla, Şule; Daylan, Benay; Demirci, Betül; Demirci, Fatih (MDPI, 2020)The air-dried aerial parts of Phlomis russeliana (Sims) Lag. Ex Benth. was extracted by methanol and fractionated by n-hexane, dichloromethane, and ethyl acetate, respectively. The wound healing properties of P. russeliana ... -
In vivo wound-healing and in vitro antibacterial and antioxidant of Carduus extract
Şakul, Ayşe Arzu; Ayla, Şule; Okur, Mehmet Evren; Karadağ, Ayşe Esra; Daylan, Benay; Güzel, Elif; Özdemir, Ekrem Musa; Günal, Mehmet Yalçın (Marmara University, 2023)Carduus adpressus has been used for its anti-hair loss effect in traditional folk medicine. The plant species is mainly distributed in Turkiye, Bulgaria, and the Western Caucasus. The studies on this specific plant in the ... -
In vivo wound-healing and in vitro antibacterial and antioxidant properties of Carduus adpressus extract
Şakul, Ayşe Arzu; Ayla, Şule; Okur, Mehmet Evren; Karadağ, Ayşe Esra; Daylan, Benay; Güzel, Elif; Özdemir, Ekrem Musa; Günal, Mehmet Yalçın (Marmara University, 2023)Carduus adpressus has been used for its anti-hair loss effect in traditional folk medicine. The plant species is mainly distributed in Türkiye, Bulgaria, and the Western Caucasus. The studies on this specific plant in the ... -
A novel approach for skin infections: Controlled release topical mats of poly (lactic acid)/poly(ethylene succinate) blends containing Voriconazole
Üstündağ Okur, Neslihan; Filippousi, Maria; Okur, Mehmet Evren; Ayla, Şule; Çağlar, Emre Şefik; Yoltaş, Ayşegül; Siafaka, Panoraia I (Elsevier Science Bv, 2018)The oral and injectable formulations of Voriconazole (VRZ), a known antifungal agent with low solubility, seem to cause severe side effects. Consequently, topical application of VRZ could be advantageous for skin fungal ... -
Opuntia ficus indica fruits ameliorate cisplatin-induced nephrotoxicity in mice
Okur, Mehmet Evren; Ayla, Şule; Karadağ, Ayşe Esra; Polat, Derya Çiçek; Demirci, Sibel; Seçkin, İsmail (Pharmaceutical Society of Japan, 2020)This study aims to determine the potential renal protective effects of Opuntia ficus-indica (L.) Miller (OFI) fruits against cisplatin-induced nephrotoxicity in mice. The antioxidant activity of OH methanol extract was ... -
Preparation, optimization and in vivo anti-inflammatory evaluation of hydroquinone loaded microemulsion formulations for melasma treatment
Üstündaǧ Okur, Neslihan; Çağlar, Emre Şefik; Pekcan, Ahmet Nezihi; Okur, Mehmet Evren; Ayla, Şule (Marmara University, 2019)The aim of the study is to evaluate the strengthening of penetration of the epidermis through the formulas containing hydroquinone in melasma treatment and development of alternative new carrier systems. During preparation ... -
Prognostic significance of tumor tissue NeuGcGM3 ganglioside expression in patients receiving racotumomab immunotherapy
Üskent, Necdet; Ayla, Şule; Molinas Mandel, Nil; Özkan, Metin; Teomete, Mehmet; Baloğlu, Hüseyin; Aydinçer, Cenk; Yergök, Hale; Doğan, Ender; Berk, Barkın; Yazar, Aziz (Hindawi Ltd., 2020)Expression ofN-glycolyl GM3 (NeuGcGM3) ganglioside was detected in the tumor specimens of patients who were on Racotumomab anti-idiotype vaccine maintenance treatment, and prognostic significance as a biomarker was ... -
Prunus spinosa L. meyvelerinin deneysel yara iyileşmesi üzerine etkileri
Ayla, Şule; Günal, Mehmet Yalçın; Sayın Şakul, Ayşe Arzu; Biçeroğlu, Özge; Özdemir, Ekrem Musa; Okur, Mehmet Evren; Polat, Derya Çiçek; Üstündağ Okur, Neslihan; Bilgiç, Bülent Emre (2017)Farelerde oluşturduğumuz deneysel yara modellerinde, Prunus Spinosa L. metanollü meyve ekstresini kullanarak, bu ekstrenin yara iyileşmesindeki etkisini araştırdık. Otuz iki adet C57/Black fare ile 4 deney grubu oluşturuldu. ... -
Wound healing activity of arum maculatum
Arzu Şakul, Ayşe; Okur, Mehmet Evren; Ayla, Şule; Daylan, Benay; Karadağ, Ayşe Esra; Batur, Şebnem; Özdemir, Ekrem Musa; Altınalan, Ebrar; Günal, Mehmet Yalçın (Istanbul Medeniyet University, 2023)Objective: In this study, the antioxidant properties of Arum maculatum plant were evaluated. This study reported for the first time the wound healing activity of the methanol extract of A. maculatum fruits. This study aimed ... -
Wound healing effect of naringin gel in alloxan induced diabetic mice
Okur, Mehmet Evren; Şakul, Ayşe Arzu; Ayla, Şule; Karadağ, Ayşe Esra; Şahin Şenyüz, Cemre; Batur, Şebnem; Daylan, Benay; Özdemir, Ekrem Musa; Palabıyık-Yücelik, Sezin; Sipahi, Hande; Aydın, Ahmet (Ankara University Faculty of Pharmac, 2020)Objective: The aim of this study was to investigate the effects of naringin, a known flavonoid, on in vitro cytotoxicity, irritation and in vivo potential efficacy when topically applied to the diabetic wound. Material and ...