Başlık için Makale Koleksiyonu listeleme
Toplam kayıt 280, listelenen: 164-183
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Laurocerasus officinalis Roem. fruit extract induces cell death through caspase mediated apoptosis in gastric cancer cell lines
(Walter de Gruyter GmbH, 2021)Objectives: Laurocerasus officinalis Roem. fruits are traditionally used for several health problems. Although there are some studies about its antiproliferative effects on different cancer cells, no study was reported ... -
Matrin ve oksimatrinin mikrobiyal transformasyonu ve metabolitlerinin in vitro biyolojik aktivitelerinin incelenmesi
(Mersin Üniversitesi, 2020)Amaç: Matrin ve oksimatrin bileşiklerinin mikrobiyal transformasyon yolu ile metabolitlerin karşılaştırmalı olarak biyolojik aktivitelerinin incelenmesi hedeflenmiştir. Yöntem:30 farklı mikroorganizmanın sıvı besiyerinde ... -
Melatonin ameliorates oxidative DNA damage and protects against formaldehyde-induced oxidative stress in rats
(E-Century Publishing Corp, 2017)Formaldehyde (FA) is an organic chemical which is widely used all over the world and has hazardous effects for the environment. FA can react with many biomolecules in the biological systems and lead to toxic effects on ... -
Microwave supported synthesis of some novel 1,3-Diarylpyrazino[1,2-a] benzimidazole derivatives and investigation of their anticancer activities
(Elsevier, 2011)The syntheses of 1,3-diarylpyrazino[1,2-a]benzimidazole derivatives and the investigation of their anticancer activities were studied. For this, 2-aryloylbenzimidazole derivatives were reacted with 2-bromoacetophenones in ... -
Miyokardiyal iskemi sonrası gelişen akut böbrek hasarı üzerine Nebivolol’ün etkisi: Preklinik bir çalışma
(Galenos Yayıncılık, 2018)Amaç: Akut miyokard iskemisinin reperfüzyonu (IR) sırasında miyokard dokusunun yanı sıra diğer dokularda da hasarın söz konusu olduğu gösterilmiştir. Böbrek hasarı bunlardan birisidir. Altta yatan mekanizmalara yönelik pek ... -
Molecular modelling and activity analysis of mycobacterium tuberculosis DNA gyrase B ATPase active site
(University of Istanbul, 2017)Computer-based algorithms and statistical techniques such as receiver operating characteristic (ROC) curves are increasingly used for the design of new ligands. X-ray crystallographic data and homology models allow examining ... -
Molecular modelling and compound activity of the escherichia coli and staphylococcus aureus DNA gyrase B ATPase site
(University of Istanbul, 2017)Development of new treatment ligands that can distinguish Escherichia coli (E. coli) from Staphylococcus aureus (S. aureus) is important because of bacterium multiple drug resistance. High-throughput virtual screening ... -
Morphological and biochemical investigation of the protective effects of panax ginseng on methotrexate-induced testicular damage
(Istanbul University Press, 2023)Objective: Methotrexate (MTX) is a chemotherapeutic agent that causes testicular toxicity used in the cure of various types of cancer. The anti-oxidant and anti-cancer effects of Panax ginseng (PxG) have been reported in ... -
Multiple online-HPLC methodologies and biological properties of leaves and stem barks extracts of Chrysanthellum indicum
(Elsevier Inc., 2024)Chrysanthellum indicum, an annual herb with yellow flowers, is used as a functional food in Asia and Africa for health purposes. In this study, we thoroughly investigated the characterization of phytochemicals within C. ... -
Nafion/aquivion-based composite lithium ion exchange membranes for high capacity Li-S batteries
(Wiley-VCH Verlag GmbH, 2022)Lithiated Nafion (Li-Naf) and lithiated Aquivion (Li-Aqu) ion exchange membranes are applied as electrolyte and separator to prevent the polysulfide shuttle effect in Li−S batteries. The production and characterization of ... -
Nanofibrous wound dressing material by electrospinning method
(Taylor & Francis As, 2019)Wound dressings are very useful materials for accelerating the wound healing process. In this study, nanofibrous wound dressings were produced from blending solution of Poly-lactic acid(PLA)/Chitosan(C)/Starch(S)/Zinc ... -
Nanofiller-based novel hybrid composite membranes for high-capacity lithium-sulfur batteries
(John Wiley and Sons Inc, 2023)Herein, Al2O3 nanofiller-reinforced lithiated Nafion:Aquivion hybrid composite ion-exchange membranes have been produced by mixing lithiated Nafion and Aquivion ionomers. After the electrochemical tests, the Li-Naf : ... -
Neopapillarine, an unusual coumarino-alkaloid from the root extract of neocryptodiscus papillaris with cytotoxic activity on renal cancer cells
(MDPI, 2020)Several simple and prenylated coumarin derivatives were isolated from the dichloromethane extract of the root of Neocryptodiscus papillaris based on moderate cytotoxic activity of the extract in COLO205, KM12 and MCF7 ... -
New 8-heterocyclic xanthine derivatives as antiproliferative agents: Synthesis and biological evaluation
(2024)This research focuses on the synthesis, characterization, and evaluation of the anti-cancer activity of novel 8-aryl substituted 1,3-diethylxanthine derivatives. The anti-proliferative activities of all the compounds were ... -
New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents
(Elsevier Science Bv, 2017)The synthesis of 3-[3/4-(2-aryl-2-oxoethoxy) arylidene] chroman/thiochroman-4-one derivatives (1-34) and evaluation of their anticancer activities were aimed in this work. Final compounds were obtained in multistep synthesis ... -
New therapeutic system based on hydrogels for vaginal candidiasis management: Formulation-characterization andin vitroevaluation based on vaginal irritation and direct contact test
(Taylor and Francis Ltd., 2020)The objective of the present research was to examine the possible usage of terbinafine loaded hydrogels for vaginal application as part of vaginal candidiasis treatment. Vaginal candidiasis belongs to the most frequent ... -
A new type of Anatolian propolis: Evaluation of its chemical composition, activity profile and botanical origin
(Wiley, 2019)This study was undertaken to analyze the phenolic profiles of 19 propolis samples from Turkey by using a high-performance thin-layer chromatographic (HPTLC) method in order to identify their plant origins. Furthermore, ... -
Nitric oxide mediated effects of nebivolol on erectile function in rats with heart failure
(IMR Press, 2022)Background and objective: Heart failure (HT) is a common complication of cardiovascular disease, which leads to functional cardiac abnormalities. Beta-blockers are commonly used to reduce mortality in HF patients; however, ... -
Non-covalent functionalization of single walled carbon nanotubes with pyrene pendant polyester: A DFT supported study
(Elsevier, 2020)Non-covalent attachment onto single-walled carbon nanotubes (SWCNTs) by protecting nanotubes' intrinsic properties has an important role in development of hybrid composite materials. Herein, we present non-covalent ... -
A novel approach for skin infections: Controlled release topical mats of poly (lactic acid)/poly(ethylene succinate) blends containing Voriconazole
(Elsevier Science Bv, 2018)The oral and injectable formulations of Voriconazole (VRZ), a known antifungal agent with low solubility, seem to cause severe side effects. Consequently, topical application of VRZ could be advantageous for skin fungal ...
