Başlık için Eczacılık Fakültesi listeleme
Toplam kayıt 339, listelenen: 297-316
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Synthesis and anticancer activity of some 1,2,3-trisubstituted pyrazinobenzimidazole derivatives
(Taylor & Francis, 2014)The synthesis of some new pyrazino[1,2-a]benzimidazole derivatives and investigation of their anticancer activities were aimed in this work. Thus, 2-acetylbenzimidazole was reacted with appropriate alpha-bromoacetophenones ... -
Synthesis and anticancer activity of some 1H-inden-1-one substituted (heteroaryl)acetamide derivatives
(Bentham Science Publishers Ltd., 2019)Background: The synthesis of 2-[3/4-((6-substituted-1-oxo-2,3-dihydro-1H-inden-2ylidene) methyl)phenoxy]-N-(heteroaryl)acetamide derivatives and the investigation of their anticancer activity were studied. Methods: ... -
Synthesis and anticancer activity of some 2-[3/4-(2-substituted phenyl-2-oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one derivatives
(Bentham Science Publishers, 2014)The synthesis of 2-[3/ 4-(2-substituted phenyl-2-oxoethoxy) benzylidene]-6-substituted-2,3-dihydro-1H-inden-1one derivatives and the investigation of their anticancer activity were studied. 2-(3- or 4-Hydroxybenzylidene) ... -
Synthesis and antifungal activities of some aryl naphthofuran ketoximes
(Bentham Science, 2011)In this study, some aryl naphtho[2, 1-b]furan-2-yl ketoximes and their ethers and esters were synthesised. The structure elucidation of the compounds was performed by IR, 1H-NMR and MASS spectroscopic data and elemental ... -
Synthesis and antifungal activity evaluation of New 1,2,4-triazole derivatives bearing salicylidene hydrazide moiety
(Bentham Science Publ Ltd, 2016)A series of new N'-(arylidene)-2-[(1-(4-nitrophenyl)-1H-1,2,4-triazol-3-yl)oxy]acetohydrazide derivatives (116) were prepared and tested for theira ntifungal activity against six plant pathogens, three human pathogens and ... -
Synthesis and antimicrobial activity evaluation of novel nitrofuranthiazoles
(University of Istanbul, 2016)In this work, six novel 4-aryl-2-[2-((5-nitrofuran-2-yl)methylene)hydrazinyl] thiazole derivatives (2a-f) were synthesized starting from 5-nitro-2-furaldehyde diacetate by using Hantzsch thiazole synthesis. The antimicrobial ... -
Synthesis and antimycobacterial activity evaluation of isatin-derived 3- [(4-aryl-2-thiazolyl])hydrazone]-1H-indol-2,3-diones
(University of Istanbul, 2017)A series of 3-[(4-aryl-2-thiazolyl)hydrazone]-1H-indol-2,3-dione derivatives (2a-f) were designed and synthesized using isatin as starting material. The obtained thiazole compounds were screened to investigate their ... -
Synthesis and antiproliferative activity of 2-arylidene 6-(2-aryl-2-oxoethoxy) benzofuran-3-one derivatives
(Bentham Science Publ Ltd, 2016)The synthesis of 2-arylidene 6-(2-aryl-2-oxoethoxy) benzofuran-3-one derivatives was reported and selected compounds were determined for their anticancer activity evaluation in National Cancer Institute NCI, USA according ... -
Synthesis and antiproliferative evaluation of new 1,3,5-trisubstituted 1,2,4-triazole derivatives against glioblastoma cell lines
(Wiley, 2023)A series of novel 1,3,5-trisubstituted-1,2,4-triazole derivatives were successfully synthesized from the starting materials of caffeic acid (CA) and ferulic acid (FA) in moderate to good yields (45-71 %). All novel compounds ... -
Synthesis and antitumor activity evaluation of new 2-(4-aminophenyl)benzothiazole derivatives bearing different heterocyclic rings
(Taylor & Francis, 2015)Twenty-five new N-[4-(benzothiazole-2-yl)phenyl]acetamide derivatives bearing different heterocyclic ring systems were synthesized using 2-(4-aminophenyl)benzothiazole structure as a pharmacophoric group. Final compounds ... -
Synthesis and biological evaluation of some 1,2-disubstituted benzimidazole derivatives as new potential anticancer agents
(2013)The synthesis of some new 1-(2-aryl-2-oxoethyl)-2-[(morpholine-4-yl)thioxomethyl]benzimidazole derivatives and investigation of their anticancer activities were the aims of this work. 2-(Chloromethyl)benzimidazole compound ... -
Synthesis and characterization of novel oxime derivatives
(Bentham Science Publ Ltd, 2016)Background: The synthesis of effective drugs are very important for the scientist. The various biological effects of the thiazole, oxime and ether functional groups are well known properties by the drug developers. So we ... -
Synthesis and characterizations of novel thiazolyl-thiadiazole derivatives as telomerase activators
(Scientific Technical Research Council Turkey-Tubitak, 2018)Pyridine-3/4-thiocarboxamide derivatives were used as starting materials for the synthesis of the target compounds. The pyridine-3/4-thiocarboxamide derivatives were reacted with ethyl 2-chloroacetoacetate in ethanol to ... -
Synthesis and in vitro antitumor activities of novel thioamide substituted piperazinyl-1,2,4-triazines
(Wiley, 2022)Triazines are in great interest for their potential to mimic nucleoside analog compounds. Three different isomers exist including 1,2,3-triazine, 1,3,5-triazine (s-triazine) and 1,2,4-triazine. All of these skeletons were ... -
Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives
(2013)In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl) thio]-1-(aryl)ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the ... -
Synthesis of 2-[4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio]-N-(thiazole-2-yl)acetamide derivatives and their anticancer activities
(Springer Birkhauser, 2013)In this work, 2-(4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio)-N-(thiazol-2-yl) acetamide derivatives were synthesized by reacting 4,5-dimethyl-1-(phenylamino)-1H-imidazole-2(3H)-thione derivatives with some ... -
Synthesis of new imidazo[1,2-a]pyridine triazole hybrid molecules as potential apoptotic antitumor agents
(John Wiley and Sons Inc, 2024)Novel imidazo[1,2-a]pyridines bearing 1,2,3-triazole moieties at the C3 position were synthesized. After the characterization of the synthesized compounds, their in vitro therapeutic activities were evaluated in various ... -
Synthesis of novel 3, 5, 6-trisubstituted triazine derivatives and their biological activity evaluation as potential antitumor and anti-inflammatory agents
(University of Istanbul, 2016)In this study, new 3, 5, 6-trisubstituted 1, 2, 4-triazine derivatives (1-9) were synthesized and their structures were determined by using NMR, IR and Mass spectroscopic methods. In vitro antitumor activities against MCF-7 ... -
Synthesis of some 2,3,6,8-tetraarylimidazo[1,2-a]pyrazine derivatives by using either reflux or microwave irradiation method, and investigation their anticancer activities
(Scientific Technical Research Council Turkey, 2011)In this study, some 2,3,6,8-tetraarylimidazo[1,2-a]pyrazine derivatives were synthesized by reacting 1-(2-aryl-2-oxoethyl)-2-aryloyl-4,5-diarylimidazoles from 2-aryloyl-4,5-diarylimidazole and 2-bromoacetophenone derivatives ... -
Synthesis of some 5,6-diaryl-1,2,4-triazine derivatives and investigation of their cyclooxygenase (COX) inhibitory activity
(Taylor & Francis Ltd, 2022)Within this study, 20 2-[(5,6-diaryl-1,2,4-triazin-3-yl)thio]-N-(benzo/thiazol-2-yl)acetamide derivatives (4a-4t) were synthesized and COX inhibitory activities of the compounds were investigated. Compounds 4k-4o, which ...
