Synthesis and anticancer activity of some 1H-inden-1-one substituted (heteroaryl)acetamide derivatives
Erişim
info:eu-repo/semantics/closedAccessTarih
2019Yazar
Karaburun, Ahmet ÇağrıGündoğdu-Karaburun, Nalan
Yurttaş, Leyla
Kayagil, İsmail
Demirayak, Şeref
Üst veri
Tüm öğe kaydını gösterKünye
Karaburun, A. Ç., Gündoğdu Karaburun, N., Yurttaş, L., Kayagil, İ. ve Demrayak, Ş. (2019). Synthesis and anticancer activity of some 1H-inden-1-one substituted (heteroaryl)acetamide derivatives. Letters in Drug Design & Discovery, 16(2), 111-118. https://dx.doi.org/10.2174/1570180815666180606081042Özet
Background: The synthesis of 2-[3/4-((6-substituted-1-oxo-2,3-dihydro-1H-inden-2ylidene) methyl)phenoxy]-N-(heteroaryl)acetamide derivatives and the investigation of their anticancer activity were studied. Methods: 2-(3/4-Hydroxybenzylidene)-6-substituted-2,3-dihydro-1H-inden-1-ones were reacted with suitable 2-chloroacetamides to give 2-[3/4-((6-substituted-1-oxo-2,3-dihydro-1H-inden-2-ylidene)methyl) phenoxy]-N-(heteroaryl) acetamide derivatives. Results: The structure elucidation of the newly synthesised 16 compounds was performed by IR, 1H-NMR, mass spectroscopic data and elemental analyses. The anticancer screening was carried out in National Cancer Institute (NCI), USA. Conclusion: Compound 3e (2-(3-((6-chloro-1-oxo-2,3-dihydro-1H-inden-2-ylidene) methyl)phenoxy)N-(thiazol-2-yl)acetamide), exhibited highest growth inhibition against the leukaemia (61.47%), non-small cell lung cancer (79.31%) and breast cancer (62.82%) cell lines.
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Q2Kaynak
Letters in Drug Design & DiscoveryCilt
16Sayı
2Bağlantı
https://dx.doi.org/10.2174/1570180815666180606081042https://hdl.handle.net/20.500.12511/1786
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