Synthesis and anticancer activity of some 1H-inden-1-one substituted (heteroaryl)acetamide derivatives
AuthorKaraburun, Ahmet Çağrı
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CitationKaraburun, A. Ç., Gündoğdu Karaburun, N., Yurttaş, L., Kayagil, İ. ve Demrayak, Ş. (2019). Synthesis and anticancer activity of some 1H-inden-1-one substituted (heteroaryl)acetamide derivatives. Letters In Drug Design & Discovery, 16(2), 111-118. https://dx.doi.org/10.2174/1570180815666180606081042
Background: The synthesis of 2-[3/4-((6-substituted-1-oxo-2,3-dihydro-1H-inden-2ylidene) methyl)phenoxy]-N-(heteroaryl)acetamide derivatives and the investigation of their anticancer activity were studied. Methods: 2-(3/4-Hydroxybenzylidene)-6-substituted-2,3-dihydro-1H-inden-1-ones were reacted with suitable 2-chloroacetamides to give 2-[3/4-((6-substituted-1-oxo-2,3-dihydro-1H-inden-2-ylidene)methyl) phenoxy]-N-(heteroaryl) acetamide derivatives. Results: The structure elucidation of the newly synthesised 16 compounds was performed by IR, 1H-NMR, mass spectroscopic data and elemental analyses. The anticancer screening was carried out in National Cancer Institute (NCI), USA. Conclusion: Compound 3e (2-(3-((6-chloro-1-oxo-2,3-dihydro-1H-inden-2-ylidene) methyl)phenoxy)N-(thiazol-2-yl)acetamide), exhibited highest growth inhibition against the leukaemia (61.47%), non-small cell lung cancer (79.31%) and breast cancer (62.82%) cell lines.