Ara
Toplam kayıt 75, listelenen: 21-30
An efficient approach to access 2,5-disubstituted 1,3,4-oxadiazoles by oxidation of 2-arenoxybenzaldehyde N-acyl hydrazones with molecular iodine
(Wiley-VCH Verlag, 2022)
An oxidative cyclization of 2-arenoxybenzaldehyde N-acyl hydrazones 3 a-o was employed to synthesize new 2,5-disubstituted 1,3,4-oxadiazole compounds 4 a-d, 4 f-i, 4 k-n. This method involves oxidative cyclization of ...
Comparison of pediatric antibiotic prescribing practice between low and high prescribers for children in primary care
(Turkish National Pediatric Society, 2022)
Background. Antibiotic prescribing is more prevalent in children. Many factors influence this practice, including the burden of outpatient visits. We aimed to compare antibiotic prescribing for children by low prescribers ...
Phosphorylation of PI3K/Akt at Thr308, but not phosphorylation of MAPK kinase, mediates lithium-induced neuroprotection against cerebral ischemia in mice
(Academic Press Inc., 2022)
Lithium, in addition to its effect on acute and long-term bipolar disorder, is involved in neuroprotection after ischemic stroke. Yet, its mechanism of action is still poorly understood, which was only limited to its ...
Stratification of the gut microbiota composition landscape across the alzheimer's disease continuum in a Turkish cohort
(American Society for Microbiology, 2022)
Alzheimer's disease (AD) is a heterogeneous disorder that spans a continuum with multiple phases, including preclinical, mild cognitive impairment, and dementia. Unlike for most other chronic diseases, human studies reporting ...
Two phases of macrophages: Inducing maturation and death of oligodendrocytes in vitro co-culture
(Elsevier B.V., 2022)
Background: The plasticity of macrophages in the immune response is a dynamic situation dependent on external stimuli. The activation of macrophages both has beneficial and detrimental effects on mature oligodendrocytes ...
The essential menopause curriculum for healthcare professionals: A European Menopause and Andropause Society (EMAS) position statement
(Elsevier Ireland Ltd, 2022)
Introduction: The menopause, or the cessation of menstruation, is a stage of the life cycle which will occur in all women. Managing perimenopausal and postmenopausal health is a key issue for all areas of healthcare, not ...
Conventional white light imaging-assisted transurethral resection of bladder tumour (TURBT) versus IMAGE1S-assisted TURBT in non-muscle-invasive bladder cancer patients: Trial protocol and 18 months results
(Springer, 2022)
Purpose White light (WL) is the traditional imaging modality for transurethral resection of bladder tumour (TURBT). IMAGE1S is a likely addition. We compare 18-mo recurrence rates following TURBT using IMAGE1S versus WL ...
Mechanistic insight into impact of phosphorylation on the enzymatic steps of farnesyltransferase
(Wiley, 2022)
Farnesyltransferase (FTase) is a heterodimeric enzyme, which catalyzes covalent attachment of the farnesyl group to target proteins, thus coordinating their trafficking in the cell. FTase has been demonstrated to be highly ...
Ferritin – From iron, through inflammation and autoimmunity, to COVID-19
(Academic Press, 2022)
While it took decades to arrive to a conclusion that ferritin is more than an indicator of iron storage level, it took a short period of time through the COVID-19 pandemic to wonder what the reason behind high levels of ...
Nitric oxide biosensor uncovers diminished ferrous iron-dependency of cultured cells adapted to physiological oxygen levels
(Elsevier B.V., 2022)
Iron is an essential metal for cellular metabolism and signaling, but it has adverse effects in excess. The physiological consequences of iron deficiency are well established, yet the relationship between iron supplementation ...