dc.contributor.author | Macit, Çağlar | |
dc.contributor.author | Ede Pazarbaşı, Seren | |
dc.contributor.author | Yılmaz Karaoğlu, Sümeyye | |
dc.contributor.author | Tunali Akbay, Tuğba | |
dc.contributor.author | Karakaya Çimen, Fatma Bedia | |
dc.contributor.author | Ercan, Feriha | |
dc.contributor.author | Şener, Göksel | |
dc.date.accessioned | 2023-10-03T06:54:16Z | |
dc.date.available | 2023-10-03T06:54:16Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Macit, Ç., Ede Pazarbaşı, S., Yılmaz Karaoğlu, S., Tunali Akbay, T., Karakaya Çimen, F. B., Ercan, F. ... Şener, G. (2023). Panax ginseng extract ameliorates methotrexate-induced multi-organ damage via the regulation of oxidative stress. Journal of Research in Pharmacy, 27(5), 1974-1988. https://doi.org/10.29228/jrp.477 | en_US |
dc.identifier.issn | 2630-6344 | |
dc.identifier.uri | https://doi.org/10.29228/jrp.477 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/11517 | |
dc.description.abstract | Oxidative damage plays an important role in organ toxicities caused by methotrexate (MTX). This study aimed to determine the antioxidant effects of Panax ginseng (PxG) extract against MTX-induced liver, lung, ileum and kidney damage. Twenty-four Sprague Dawley male rats (weight 250-300 g) were used in the study. The animals were randomly separated into three groups: a) Control, b) MTX-treated (MTX) and c) MTX+PxG-treated (MTX+PxG) groups. MTX was administered intraperitoneally at 20 mg/kg, as a single dose to MTX and MTX+PxG groups. PxG was administered orally at 100 mg/kg to the MTX+PxG group for five days. Saline was given to the control and MTX groups for 5 days. At the end of the experiment, liver, lung, ileum, and kidney samples were obtained. Malondialdehyde (MDA) and glutathione (GSH) levels, superoxide dismutase (SOD), glutathione-S-transferase (GST) and tissue factor (TF) activities were determined in all tissues. In addition, histological examinations were done through light microscopy. GraphPad Prism 5v. was used for statistics, and p[removed]. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Marmara University | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Antioxidant Activity | en_US |
dc.subject | Ileum | en_US |
dc.subject | Kidney | en_US |
dc.subject | Liver | en_US |
dc.subject | Lung | en_US |
dc.subject | Methotrexate | en_US |
dc.subject | Panax Ginseng Extract | en_US |
dc.title | Panax ginseng extract ameliorates methotrexate-induced multi-organ damage via the regulation of oxidative stress | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Research in Pharmacy | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-5532-2395 | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 1974 | en_US |
dc.identifier.endpage | 1988 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.29228/jrp.477 | en_US |
dc.institutionauthor | Macit, Çağlar | |
dc.identifier.wos | 001069183100019 | en_US |
dc.identifier.scopus | 2-s2.0-85171323419 | en_US |
dc.identifier.scopusquality | Q3 | en_US |