Panax ginseng extract ameliorates methotrexate-induced multi-organ damage via the regulation of oxidative stress
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2023Author
Macit, ÇağlarEde Pazarbaşı, Seren
Yılmaz Karaoğlu, Sümeyye
Tunali Akbay, Tuğba
Karakaya Çimen, Fatma Bedia
Ercan, Feriha
Şener, Göksel
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Macit, Ç., Ede Pazarbaşı, S., Yılmaz Karaoğlu, S., Tunali Akbay, T., Karakaya Çimen, F. B., Ercan, F. ... Şener, G. (2023). Panax ginseng extract ameliorates methotrexate-induced multi-organ damage via the regulation of oxidative stress. Journal of Research in Pharmacy, 27(5), 1974-1988. https://doi.org/10.29228/jrp.477Abstract
Oxidative damage plays an important role in organ toxicities caused by methotrexate (MTX). This study aimed to determine the antioxidant effects of Panax ginseng (PxG) extract against MTX-induced liver, lung, ileum and kidney damage. Twenty-four Sprague Dawley male rats (weight 250-300 g) were used in the study. The animals were randomly separated into three groups: a) Control, b) MTX-treated (MTX) and c) MTX+PxG-treated (MTX+PxG) groups. MTX was administered intraperitoneally at 20 mg/kg, as a single dose to MTX and MTX+PxG groups. PxG was administered orally at 100 mg/kg to the MTX+PxG group for five days. Saline was given to the control and MTX groups for 5 days. At the end of the experiment, liver, lung, ileum, and kidney samples were obtained. Malondialdehyde (MDA) and glutathione (GSH) levels, superoxide dismutase (SOD), glutathione-S-transferase (GST) and tissue factor (TF) activities were determined in all tissues. In addition, histological examinations were done through light microscopy. GraphPad Prism 5v. was used for statistics, and p[removed].
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Journal of Research in PharmacyVolume
27Issue
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