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dc.contributor.authorUmar, Rashida Muhammad
dc.contributor.authorCan, Zeynep Yeşim
dc.contributor.authorGüven Eke, Ece
dc.contributor.authorKarataş Koçberber, Emine
dc.contributor.authorÖlmez, Ömer Fatih
dc.date.accessioned2023-05-08T07:30:08Z
dc.date.available2023-05-08T07:30:08Z
dc.date.issued2023en_US
dc.identifier.citationUmar, R. M., Can, Z. Y., Güven Eke, E., Karataş Koçberber, E. ve Ölmez, Ö. F. (2023). The prevalence of drug-drug interactions and reported therapy related side-effects in oncology out-patients. Clinical and Experimental Health Sciences, 13(1), 212-217. https://doi.org/10.33808/clinexphealthsci.1099582en_US
dc.identifier.issn2459-1459
dc.identifier.urihttps://doi.org/10.33808/clinexphealthsci.1099582
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10914
dc.description.abstractObjective: The use of multiple medications in cancer patients is unavoidable; thus, adverse drug-drug interactions are frequent. This study aims to assess the prevalence of potential drug interactions in oncology patients visiting the outpatient chemotherapy unit. Method: Demographic and health-related information of patients visiting an outpatient chemotherapy unit was recorded using a pre-prepared form. A comprehensive list of all concurrently used medications was compiled and checked for interactions with the Micromedex online drug interaction tool.Results: A total of 179 adult patients were included. We recorded an average of 9.3 drugs per patient with 79 patients using more than 10 drugs. A total of 1671 drugs including 303 chemotherapeutic agents were assessed for drug-drug interactions. A total of 374 interactions, of which 203 were significant, were recorded in 118 (65.9%) patients with an average of 3.2 interactions per patient. Only 46 major interactions were recorded for anticancer agents. Cyclophosphamide (n=13) and cisplatin (n=12) were involved in most interactions. The number of interactions correlated with the number of drugs used (p=.001) and the presence of comorbidities (p=.002). The presence of comorbidities increased the risk of interaction by 1.21 (p=.04). Recorded side effects were not correlated to drug interactions. Conclusion: Medication review in cancer patients is essential in establishing all medications used by patients. Routine assessment in terms of potential drug interactions and evaluation of these interactions by a qualified pharmacist may help in optimizing patient outcomes.en_US
dc.language.isoengen_US
dc.publisherMarmara Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectCancer Patientsen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectDrug-Drug Interactionen_US
dc.subjectSide Effectsen_US
dc.subjectPolypharmacyen_US
dc.titleThe prevalence of drug-drug interactions and reported therapy related side-effects in oncology out-patientsen_US
dc.typearticleen_US
dc.relation.ispartofClinical and Experimental Health Sciencesen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Klinik Eczacılık Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0001-8902-7274en_US
dc.authorid0000-0002-9053-5038en_US
dc.authorid0000-0001-7934-7039en_US
dc.identifier.volume13en_US
dc.identifier.issue1en_US
dc.identifier.startpage212en_US
dc.identifier.endpage217en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.33808/clinexphealthsci.1099582en_US
dc.institutionauthorUmar, Rashida Muhammad
dc.institutionauthorGüven Eke, Ece
dc.institutionauthorÖlmez, Ömer Fatih
dc.identifier.wos000960484800028en_US
dc.identifier.trdizinid1162648en_US


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