The prevalence of drug-drug interactions and reported therapy related side-effects in oncology out-patients
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Erişim
info:eu-repo/semantics/openAccessAttribution-NonCommercial 4.0 Internationalhttps://creativecommons.org/licenses/by-nc/4.0/Tarih
2023Yazar
Umar, Rashida MuhammadCan, Zeynep Yeşim
Güven Eke, Ece
Karataş Koçberber, Emine
Ölmez, Ömer Fatih
Üst veri
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Umar, R. M., Can, Z. Y., Güven Eke, E., Karataş Koçberber, E. ve Ölmez, Ö. F. (2023). The prevalence of drug-drug interactions and reported therapy related side-effects in oncology out-patients. Clinical and Experimental Health Sciences, 13(1), 212-217. https://doi.org/10.33808/clinexphealthsci.1099582Özet
Objective: The use of multiple medications in cancer patients is unavoidable; thus, adverse drug-drug interactions are frequent. This study aims to assess the prevalence of potential drug interactions in oncology patients visiting the outpatient chemotherapy unit. Method: Demographic and health-related information of patients visiting an outpatient chemotherapy unit was recorded using a pre-prepared form. A comprehensive list of all concurrently used medications was compiled and checked for interactions with the Micromedex online drug interaction tool.Results: A total of 179 adult patients were included. We recorded an average of 9.3 drugs per patient with 79 patients using more than 10 drugs. A total of 1671 drugs including 303 chemotherapeutic agents were assessed for drug-drug interactions. A total of 374 interactions, of which 203 were significant, were recorded in 118 (65.9%) patients with an average of 3.2 interactions per patient. Only 46 major interactions were recorded for anticancer agents. Cyclophosphamide (n=13) and cisplatin (n=12) were involved in most interactions. The number of interactions correlated with the number of drugs used (p=.001) and the presence of comorbidities (p=.002). The presence of comorbidities increased the risk of interaction by 1.21 (p=.04). Recorded side effects were not correlated to drug interactions. Conclusion: Medication review in cancer patients is essential in establishing all medications used by patients. Routine assessment in terms of potential drug interactions and evaluation of these interactions by a qualified pharmacist may help in optimizing patient outcomes.
Kaynak
Clinical and Experimental Health SciencesCilt
13Sayı
1Bağlantı
https://doi.org/10.33808/clinexphealthsci.1099582https://hdl.handle.net/20.500.12511/10914
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