Microwave supported synthesis of some novel 1,3-Diarylpyrazino[1,2-a] benzimidazole derivatives and investigation of their anticancer activities

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dc.contributor.authorDemirayak, Şeref
dc.contributor.authorKayagil, İsmail
dc.contributor.authorYurttaş, Leyla
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:55:54Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:55:54Z
dc.date.issued2011
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.descriptionWOS: 000286905400048
dc.descriptionPubMed ID: 21122952
dc.description.abstractThe syntheses of 1,3-diarylpyrazino[1,2-a]benzimidazole derivatives and the investigation of their anticancer activities were studied. For this, 2-aryloylbenzimidazole derivatives were reacted with 2-bromoacetophenones in acetone to give 1-(2-aryl-2-oxoethyl)-2-aryloylbenzimidazoles. The resulting materials were reacted with ammonium acetate in acetic acid to obtain the aimed compound. In this reaction, microwave irradiation method was applied as the reaction conditions. Anticancer activities of the compounds obtained were investigated. It was observed that some of the compounds showed remarkable anticancer activities.
dc.identifier.citationDemirayak, Ş., Kayagil, İ. ve Yurttaş, L. (2011). Microwave supported synthesis of some novel 1,3-Diarylpyrazino[1,2-a] benzimidazole derivatives and investigation of their anticancer activities. European Journal of Medical Chemistry, 46(1), 411-416. https://dx.doi.org/10.1016/j.ejmech.2010.11.007
dc.identifier.doi10.1016/j.ejmech.2010.11.007
dc.identifier.endpage416
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.issue1
dc.identifier.scopusqualityQ1
dc.identifier.startpage411
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejmech.2010.11.007
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2450
dc.identifier.volume46
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofEuropean Journal of Medical Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject2-Aryloylbenzimidazole
dc.subjectPyrazino[1,2-a]benzimidazole
dc.subjectAnticancer Activity
dc.titleMicrowave supported synthesis of some novel 1,3-Diarylpyrazino[1,2-a] benzimidazole derivatives and investigation of their anticancer activities
dc.typeArticle

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