Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice

Basit Öğe Kaydı
dc.authorid0000-0002-9354-0000
dc.authorid0000-0002-1079-8832
dc.authorid0000-0003-2143-5268
dc.authorid0000-0003-1580-8371
dc.contributor.authorSakul, Arzu
dc.contributor.authorOzansoy, Mehmet
dc.contributor.authorElibol, Birsen
dc.contributor.authorAyla, Şule
dc.contributor.authorGünal, Mehmet Yalçın
dc.contributor.authorYozgat, Yasemin
dc.contributor.authorBasağa, Hüveyda
dc.contributor.authorŞahin, Kazım
dc.contributor.authorKazancıoğlu, Rümeyza
dc.contributor.authorKılıç, Ulkan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:46Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:46Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.descriptionWOS: 000471268100003
dc.description.abstractThe clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been used in combination with cisplatin to cope with nephrotoxicity. Due to its high antitumor activity and oxygen-carrying capacity, we investigated the molecular effects of squalene against cisplatin-induced oxidative stress and kidney damage in mice. Single dose of cisplatin (7 mg/kg) was given to male Balb/c mice. Squalene (100 mg/kg/day) was administered orogastrically to mice for 10 days. Following sacrification, molecular alterations were investigated as analysis of the levels of oxidative stress index (OSI), inflammatory cytokines and cell survival-related proteins in addition to histopathological examinations in mice kidney tissue. The level OSI and Interferon-gamma (IFN-gamma) decreased in the cisplatin and squalene cotreated mice compared to cisplatin-treated mice. Squalene treatment also increased the activation of protein kinase B (AKT). Furthermore, cisplatin-induced inactivation of mammalian target of rapamycin (mTOR) and histopathological damages were reversed by squalene. It may be suggested that squalene ameliorated the cisplatin-induced histopathological damages in the kidney through activation of AKT/mTOR signaling pathway by regulating the balance of the redox system due to its antioxidative effect.
dc.identifier.citationSakul, A, Ozansoy, M., Elibol, B., Ayla, Ş., Günal, M. Y., Yozgat, Y. … Kılıç, U. (2019). Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice. Turkish Journal of Biology, 43(3), 179-188. https://dx.doi.org/10.3906/biy-1902-77
dc.identifier.doi10.3906/biy-1902-77
dc.identifier.endpage188
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue3
dc.identifier.scopusqualityQ3
dc.identifier.startpage179
dc.identifier.urihttps://dx.doi.org/10.3906/biy-1902-77
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1753
dc.identifier.volume43
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal of Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAKT
dc.subjectCisplatin-Induced Nephrotoxicity
dc.subjectMice
dc.subjectmTOR
dc.subjectOxidative-Stress
dc.subjectSqualene
dc.titleSqualene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
sakul, a..pdf
Boyut:
9.44 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu