Synthesis and biological evaluation of some 1,2-disubstituted benzimidazole derivatives as new potential anticancer agents

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dc.contributor.authorYurttaş, Leyla
dc.contributor.authorDemirayak, Şeref
dc.contributor.authorÇiftçi Akalın, Gülşen
dc.contributor.authorYıldırım Ulusoylar, Şafak
dc.contributor.authorKaplancıklı, Zafer Asım
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:33Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:33Z
dc.date.issued2013
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.description.abstractThe synthesis of some new 1-(2-aryl-2-oxoethyl)-2-[(morpholine-4-yl)thioxomethyl]benzimidazole derivatives and investigation of their anticancer activities were the aims of this work. 2-(Chloromethyl)benzimidazole compound was reacted with sulfur and morpholine via WillgerodtKindler reaction to give 2-[(morpholine-4-yl)thioxomethyl]benzimidazole. Then, the obtained compound was reacted with appropriate -bromoacetophenone derivatives in the presence of potassium carbonate to give the final products. Structure elucidation of the final compounds was achieved by FT-IR, 1H NMR spectroscopy and MS spectrometry. The anticancer activities of the final compounds were evaluated by MTT assay, BrdU method, and flow cytometric analysis on C6, MCF-7, and A549 tumor cells. Most of the synthesized compounds exhibited considerable selectivity against the MCF-7 and C6 cell lines.
dc.identifier.citationYurttaş, L., Demirayak, Ş., Çiftçi Akalın, G., Yıldırım Ulusoylar, Ş. ve Kaplancıklı, Z. A. (2013). Synthesis and biological evaluation of some 1,2-disubstituted benzimidazole derivatives as new potential anticancer agents. Archiv der Pharmazie, 346(5), 403-414. https://dx.doi.org/10.1002/ardp.201200452
dc.identifier.doi10.1002/ardp.201200452
dc.identifier.endpage414
dc.identifier.issn0365-6233
dc.identifier.issue5
dc.identifier.scopusqualityQ2
dc.identifier.startpage403
dc.identifier.urihttps://hdl.handle.net/20.500.12511/840
dc.identifier.urihttps://dx.doi.org/10.1002/ardp.201200452
dc.identifier.volume346
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofArchiv der Pharmazieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnticancer Activity
dc.subjectBenzimidazole
dc.subjectBrdu
dc.subjectFlow Cytometric Analysis
dc.subjectThioamide
dc.titleSynthesis and biological evaluation of some 1,2-disubstituted benzimidazole derivatives as new potential anticancer agents
dc.typeArticle

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