Evaluation of the effects of adipocytokines on prognosis in ischemic cerebrovascular events

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dc.authorid0000-0003-0334-811X
dc.contributor.authorDemir Türkeş, Muzaffer Şükriye Aliye
dc.contributor.authorDüz Arıcı, Özge
dc.contributor.authorIşık, Nihal
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:54Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:54Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.descriptionWOS: 000406221900002
dc.description.abstractObjective: Leptin and adiponectin are the most important adipocytokines and recent studies showed that they may have role in the etiology of ischemic stroke. However, the effect of adipocytokines on stroke is not yet well understood, and related studies are confusing. The aim of this study was to investigate the effects of serum leptin and adiponectin levels on patients with acute ischemic stroke who were admitted to hospital within 24 hours of stroke. Materials and Methods: A total of 59 patients with acute ischemic stroke and 24 healthy individuals similar in age and sex to the patients were enrolled in the study. The Rankin disability scale was performed in order to detect the severity of stroke. Levels of serum leptin and adiponectin were detected using an enzyme-linked immunosorbent assay. In addition, the outcomes of the patients were calculated through differences between the first day Rankin score and the 30th day Rankin score. Results were compared and the relation with prognosis was investigated. The correlation of leptin and adiponectin levels with stroke severity was analyzed. Results: Thirty-four male and 25 female patients were included in this study. Leptin levels of patients were higher than in the control group. Adiponectin levels did not differ between the patient and control groups. There was no correlation between serum adipocytokine levels and the modified Rankin scale. Conclusion: Serum leptin and adiponectin levels are not associated with the prognosis of ischemic stroke. Even though high levels of leptin may associate with ischemic stroke, this study was not able to show an association with stroke prognosis.
dc.description.abstractLeptin ve adiponektin, adipositokinlerin en önemlileridir ve son yıllarda yapılan çalışmalarda iskemik serebrovasküler olay etiyolojisinde rolü olduğu düşünülmektedir. Ancak adipositokinlerin inme üzerine etkisi ile ilgili yapılan çalışmaların sonuçları çelişkilidir. Bu çalışmada, iskemik inme tanısı ile ilk 24 saat içerisinde hastanemiz acil servisine başvuran hastaların serum leptin ve adiponektin düzeylerinin prognoz ile ilişkisini değerlendirmeyi amaçladık.
dc.identifier.citationDemir Türkeş, M. Ş. A., Düz Arcı, Ö. ve Işık, N. (2017). Evaluation of the effects of adipocytokines on prognosis in ischemic cerebrovascular events. Turkish Journal of Neurology, 23(2), 51-55. https://dx.doi.org/10.4274/tnd.02170
dc.identifier.doi10.4274/tnd.02170
dc.identifier.endpage55
dc.identifier.issn1301-062X
dc.identifier.issn1309-2545
dc.identifier.issue2
dc.identifier.scopusqualityQ4
dc.identifier.startpage51
dc.identifier.urihttps://dx.doi.org/10.4274/tnd.02170
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3961
dc.identifier.volume23
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTurkish Neurological Society
dc.relation.ispartofTurkish Journal of Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLeptin
dc.subjectAdiponectin
dc.subjectIschemic Stroke
dc.subjectPrognosis
dc.subjectLeptin
dc.subjectAdiponektin
dc.subjectİskemik İnme
dc.subjectPrognoz
dc.titleEvaluation of the effects of adipocytokines on prognosis in ischemic cerebrovascular events
dc.title.alternativeAdipositokinlerin iskemik serebrovasküler olaylarda prognoz üzerine etkisinin değerlendirilmesi
dc.typeArticle

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