Synthesis and antimicrobial activity evaluation of novel nitrofuranthiazoles

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dc.authorid0000-0002-5976-676X
dc.contributor.authorYurttaş, Leyla
dc.contributor.authorŞahin, Zafer
dc.contributor.authorEr, Sevda
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:15Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:15Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractIn this work, six novel 4-aryl-2-[2-((5-nitrofuran-2-yl)methylene)hydrazinyl] thiazole derivatives (2a-f) were synthesized starting from 5-nitro-2-furaldehyde diacetate by using Hantzsch thiazole synthesis. The antimicrobial activity of the title compounds were screened against five Gram positive bacteria B. cereus, E. faecalis, S. aureus, S. epidermidis, L. monocytogenes and two Gram negative bacteria E. coli and S. typhi. MIC and MBC were calculated and compared to standard drug nitrofurazone. Compounds bearing pyridine moiety (2d-e) exhibited significant antimicrobial activity which could be evaluated as new, potent antibacterial agents.
dc.identifier.citationYurttaş, L., Şahin, Z., Er, S. ve Demirayak, Ş. (2016). Synthesis and antimicrobial activity evaluation of novel nitrofuranthiazoles. Acta Pharmaceutica Sciencia, 54(1), 43-52. https://dx.doi.org/10.23893/1307-2080.APS.0544
dc.identifier.doi10.23893/1307-2080.APS.0544
dc.identifier.endpage52
dc.identifier.issn1307-2080
dc.identifier.issue1
dc.identifier.scopusqualityN/A
dc.identifier.startpage43
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1109
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.0544
dc.identifier.volume54
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversity of Istanbul
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntibacterial Activity
dc.subjectNitrofurans
dc.subjectNitrofurazone
dc.subjectThiazole
dc.titleSynthesis and antimicrobial activity evaluation of novel nitrofuranthiazoles
dc.typeArticle

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