Anatolicin, a highly potent and selective cytotoxic sesquiterpene coumarin from the root extract of heptaptera anatolica

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dc.authorid0000-0003-2533-5141
dc.contributor.authorTosun, Fatma
dc.contributor.authorBeutler, John A.
dc.contributor.authorRansom, Tanya
dc.contributor.authorMiski, Mahmut
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:39Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:39Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.descriptionWOS: 000465503800115
dc.descriptionPubMed ID: 30909537
dc.description.abstractSeven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (8), were isolated from the dichloromethane extract of the roots of Heptaptera anatolica. Structures of these compounds were elucidated based on their spectral properties. While some of these sesquiterpene coumarins showed modest cytotoxic activity against COLO205, KM12, A498, UO31, and TC32 cancer cell lines, selective cytotoxicity of anatolicin (8) and 14-acetoxybadrakemin (7) were observed at nanomolar level against the UO31 kidney cancer cell line.
dc.description.sponsorshipIntramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research [1ZIA BC01146907]; National Cancer Institute, National Institutes of Health [HHSN261200800001E]en_US
dc.description.sponsorshipThis research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research (1ZIA BC01146907) and with federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN261200800001Een_US
dc.identifier.citationTosun, F., Beutler, J. A., Ransom, T. T. ve Miski, M. (2019). Anatolicin, a highly potent and selective cytotoxic sesquiterpene coumarin from the root extract of heptaptera anatolica. Molecules, 24(6). https://dx.doi.org/10.3390/molecules24061153
dc.identifier.doi10.3390/molecules24061153
dc.identifier.issn1420-3049
dc.identifier.issue6
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.3390/molecules24061153
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1697
dc.identifier.volume24
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofMoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectHeptaptera Anatolica
dc.subjectApiaceae
dc.subjectSesquiterpene Coumarins
dc.subjectCytotoxic Activity
dc.titleAnatolicin, a highly potent and selective cytotoxic sesquiterpene coumarin from the root extract of heptaptera anatolica
dc.typeArticle

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