In vitro ACE2 and 5-LOX enzyme inhibition by menthol and three different mint essential oils
| dc.authorid | 0000-0002-3412-0807 | |
| dc.authorid | 0000-0003-1896-2729 | |
| dc.contributor.author | Demirci, Fatih | |
| dc.contributor.author | Karadağ, Ayşe Esra | |
| dc.contributor.author | Biltekin, Sevde Nur | |
| dc.contributor.author | Demirci, Betül | |
| dc.date.accessioned | 2021-12-16T08:06:34Z | |
| dc.date.available | 2021-12-16T08:06:34Z | |
| dc.date.issued | 2021 | |
| dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı | |
| dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı | |
| dc.description.abstract | Mentha arvensis L., M. citrata L., and M. spicata L. (family Lamiaceae) essential oils, and their characteristic constituent, menthol, were evaluated in vitro for angiotensin converting enzyme 2 (ACE2) and 5-lipoxygenase (5-LOX) enzyme inhibitory activity. The chemical compositions of M. arvensis, M. citrata, and M. spicata essential oils were analysed both by GC-FID, and GC/MS; 82.0%, 38.1%, and 0.4% menthol were identified, respectively. M. spicata essential oil contained 88.2% carvone as its major component. The enzyme inhibitory activities of the essential oils were evaluated using a fluorometric multiplate based enzyme inhibition kit; the ACE2 inhibitions produced by M. arvensis, M. citrata, and M. spicata essential oils were 33%, 22%, and 73%, while the 5-LOX inhibitions were 84%, 79%, and 70%, respectively. In addition, menthol also showed remarkable ACE2 inhibition of 99.8%, whereas the 5-LOX inhibition was 79.9%. As a result, menthol and the three different mint essential oils may have antiviral potential applications against coronaviruses due to their ACE2 enzyme inhibition and anti-inflammatory features. However, further in vivo studies are needed to confirm the safety and efficacy. | |
| dc.description.sponsorship | Anadolu University | en_US |
| dc.identifier.citation | Demirci, F., Karadağ, A. E., Biltekin, S. N. ve Demirci, B. (2021). In vitro ACE2 and 5-LOX enzyme inhibition by menthol and three different mint essential oils. Natural Product Communications, 16(11). https://dx.doi.org/10.1177/1934578X211055014 | |
| dc.identifier.doi | 10.1177/1934578X211055014 | |
| dc.identifier.issn | 1934-578X | |
| dc.identifier.issn | 1555-9475 | |
| dc.identifier.issue | 11 | |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.uri | https://dx.doi.org/10.1177/1934578X211055014 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/8682 | |
| dc.identifier.volume | 16 | |
| dc.identifier.wosquality | Q4 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.language.iso | en | |
| dc.publisher | SAGE Publications Inc. | |
| dc.relation.ispartof | Natural Product Communications | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | Attribution-NonCommercial 4.0 International | * |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
| dc.subject | Mentha | |
| dc.subject | Essential Oil | |
| dc.subject | ACE2 | |
| dc.subject | LOX | |
| dc.subject | Menthol | |
| dc.title | In vitro ACE2 and 5-LOX enzyme inhibition by menthol and three different mint essential oils | |
| dc.type | Article |
