Eye tracking as an objective measure of hyperphagia in children with Prader-Willi syndrome

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dc.contributor.authorKey, Alexandra P.
dc.contributor.authorZengin-Bolatkale, Hatun
dc.contributor.authorDimitropoulos, Anastasia
dc.contributor.authorDoernberg, Ellen
dc.date.accessioned2020-07-29T08:32:04Z
dc.date.available2020-07-29T08:32:04Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Dil ve Konuşma Terapisi Bölümü
dc.description.abstractThis study examined sensitivity of eye tracking measures to hyperphagia severity in Prader-Willi syndrome (PWS). Gaze data were collected in 57 children with PWS, age 3-11 years, and 47 typically developing peers at two study sites during free visual exploration of complex stimulus arrays that included images of food, animals, and household objects. Analysis of the number and duration of fixations as well as gaze perseverations revealed that food items are not exceptionally salient for children with PWS. Instead, increased attention to food in the context of other high-interest items (e.g., animals) was associated with caregiver reports of more severe hyperphagia and more advanced nutritional phase. The study also provided preliminary evidence of possible genetic subtype and sex differences as well as demonstrated that multiple investigators in a wide range of settings can effectively implement the eye tracking protocol. The results indicate that gaze characteristics derived from eye tracking may be a promising objective marker of hyperphagia in PWS for use in research and clinical trials.
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)en_US
dc.identifier.citationKey, A. P., Zengin-Bolatkale, H., Dimitropoulos, A. ve Doernberg, E. (2020). Eye tracking as an objective measure of hyperphagia in children with Prader-Willi syndrome. American Journal of Medical Genetics Part A, 182(7), 1655-1663. https://dx.doi.org/10.1002/ajmg.a.61606
dc.identifier.doi10.1002/ajmg.a.61606
dc.identifier.endpage1663
dc.identifier.issn1552-4825
dc.identifier.issn1552-4833
dc.identifier.issue7
dc.identifier.scopusqualityQ2
dc.identifier.startpage1655
dc.identifier.urihttps://dx.doi.org/10.1002/ajmg.a.61606
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5638
dc.identifier.volume182
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAmerican Journal of Medical Genetics Part Aen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectEye Tracking
dc.subjectHyperphagia
dc.subjectNutritional Phase
dc.subjectPrader-Willi Syndrome
dc.titleEye tracking as an objective measure of hyperphagia in children with Prader-Willi syndrome
dc.typeArticle

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