New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents

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dc.authorid0000-0002-0841-1299
dc.contributor.authorDemirayak, Şeref
dc.contributor.authorYurttaş, Leyla
dc.contributor.authorGündoğdu-Karaburun, Nalan
dc.contributor.authorKaraburun, Ahmet Çagrı
dc.contributor.authorKayagil, İsmail
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:58Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:58Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.descriptionWOS: 000414346300017
dc.descriptionPubMed ID: 29158716
dc.description.abstractThe synthesis of 3-[3/4-(2-aryl-2-oxoethoxy) arylidene] chroman/thiochroman-4-one derivatives (1-34) and evaluation of their anticancer activities were aimed in this work. Final compounds were obtained in multistep synthesis reactions using phenol/thiophenol derivatives as starting materials. For anticancer activity evaluation, all compounds were offered to National Cancer Institute (NCI), USA and selected ones were tested against sixty human tumor cell lines derived from nine neoplastic diseases. The activity results were evaluated according to the drug screening protocol of the institute. Compounds containing thiochromanone skeleton exhibited higher anticancer activity.
dc.description.sponsorshipAnadolu University, Turkey (BAP) [050301]en_US
dc.description.sponsorshipThis work was supported by Anadolu University, Turkey (BAP Project No: 050301). The authors present their thanks to NCI (USA) and Anadolu University BIBAM (Turkey) for anticancer test results and NMR spectra, respectively.en_US
dc.identifier.citationDemirayak, Ş., Yurttaş, L., Gündoğdu-Karaburun, N., Karaburun, A. Ç. ve Kayagil, İ. (2017). New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents. Saudi Pharmaceutical Journal, 25(7), 1063-1072. https://dx.doi.org/10.1016/j.jsps.2017.04.040
dc.identifier.doi10.1016/j.jsps.2017.04.040
dc.identifier.endpage1072
dc.identifier.issn1319-0164
dc.identifier.issn2213-7475
dc.identifier.issue7
dc.identifier.scopusqualityQ1
dc.identifier.startpage1063
dc.identifier.urihttps://dx.doi.org/10.1016/j.jsps.2017.04.040
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3775
dc.identifier.volume25
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofSaudi Pharmaceutical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChromanone
dc.subjectThiochromanone
dc.subjectBenzopyranone
dc.subjectBenzothiopyranone
dc.subjectFlavone
dc.subjectAlpha, Beta-Unsaturated Carbonyl
dc.subjectAnticancer Activity
dc.titleNew chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents
dc.typeArticle

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