Improving therapeutic efficacy of voriconazole against fungal keratitis: Thermo-sensitive in situ gels as ophthalmic drug carriers

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dc.authorid0000-0001-8018-6500
dc.authorid0000-0001-7256-3230
dc.contributor.authorÜstündağ Okur, Neslihan
dc.contributor.authorYozgatlı, Vildan
dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorYoltaş, Ayşegül
dc.contributor.authorSiafaka, Panoraia, I.
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:44Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:44Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.descriptionWOS: 000457344000037
dc.description.abstractThe aim of this research was to evaluate the potential use of in situ gel formulations for voriconazole ocular delivery as fungal keratitis treatment. The in situ gelling system was applied to increase residence time and the bioavailability of voriconazole in the ocular mucosa. Temperature-triggered in situ gel formulations were prepared by cold method. Poloxamer 188, poloxamer 407 and carboxymethylcellulose were used for the preparation of thermosensitive in situ ocular gel. Voriconazole concentration in formulations was 0.1% (w/w). The prepared gels were evaluated for clarity, sol-gel transition temperature, gelling capacity, pH, viscosity, FT-IR and drug content. The gelation temperatures of all the formulations were within the range of 29-34 degrees C. All formulations exhibited fairly uniform drug content. Furthermore, sterility, antifungal activity, stability, in vitro drug release, ex vivo permeation, and penetration and in vivo study of these formulations were also examined. Drug release results indicated that all formulations showed sustained release properties. Irritation studies showed that no ocular damage or clinically abnormal signs were observed in the cornea, conjunctiva or iris upon administration of the formulation. In conclusion, voriconazole loaded in situ gels could be offered as a promising strategy as ocular carriers for the treatment of fungal keratitis.
dc.identifier.citationÜstündağ Okur, N., Yozgatlı, V., Okur, M. E., Yoltaş, A. ve Siafaka, P. I. (2019). Improving therapeutic efficacy of voriconazole against fungal keratitis: Thermo-sensitive in situ gels as ophthalmic drug carriers. Journal of Drug Delivery Science and Technology, 49, 323-333. https://dx.doi.org/10.1016/j.jddst.2018.12.005
dc.identifier.doi10.1016/j.jddst.2018.12.005
dc.identifier.endpage333
dc.identifier.issn1773-2247
dc.identifier.scopusqualityQ2
dc.identifier.startpage323
dc.identifier.urihttps://dx.doi.org/10.1016/j.jddst.2018.12.005
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1738
dc.identifier.volume49
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVoriconazole
dc.subjectThermo-Sensitive in Situ Gel
dc.subjectOcular Drug Delivery
dc.subjectMicrobiological Study
dc.subjectEx Vivo
dc.subjectRabbit
dc.subjectOcular Irritation Test
dc.titleImproving therapeutic efficacy of voriconazole against fungal keratitis: Thermo-sensitive in situ gels as ophthalmic drug carriers
dc.typeArticle

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