The distribution of different types of diabetes in childhood: A single center experience

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dc.authorid0000-0002-1044-6888
dc.contributor.authorHaliloğlu, Belma
dc.contributor.authorAbalı, Saygın
dc.contributor.authorBuğrul, Fuat
dc.contributor.authorÇelik, Enes
dc.contributor.authorBaş, Serpil
dc.contributor.authorAtay, Zeynep
dc.contributor.authorGüran, Tülay
dc.contributor.authorTuran, Serap
dc.contributor.authorBereket, Abdullah
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:31Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:31Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000432911500006
dc.descriptionPubMed ID: 29175806
dc.description.abstractObjective: Type I diabetes (T1D) is the most common cause of diabetes in childhood but type 2 diabetes (T2D) and maturity onset diabetes of the young (MODY) are emerging as noteworthy causes of diabetes at young ages. The aim is to determine the distribution, trends and clinical features of the different types of diabetes in childhood in one tertiary center. Methods: The records of children and adolescents aged 0-18 years who were diagnosed as "diabetes/persistent hyperglycemia" between January 1999 and December 2016, were reviewed. Clinical and laboratory characteristics of the patients at diagnosis and type of diabetes were recorded. Results: The mean +/- standard deviation age of 835 patients (48.7% females) at diagnosis was 8.8 +/- 4.4 years. Eighty-four percent of the patients were diagnosed as T1D, 5.7% as T2D, 5.3% as clinical MODY and 5% as being cases of other types of diabetes. The frequency of diabetic ketoacidosis (DKA) and severe DKA in T1D were 48.4% and 11.6%, respectively. Fourteen patients (29.2 %) with T2D presented with ketosis and two of them (4.2 %) had DKA at diagnosis. Antibody positivity was 83.1 % in T1D and 14.8% in T2D. A statistically significant increase in the frequency of T2D has clearly been demonstrated in recent years with a frequency of 1.9%, 2.4% and 7.9% in 1999-2004, 2005-2010 and 2011-2016, respectively (p <0.001). In MODY, genetic analysis was performed in 26 (59%) patients and NNF1A and GCK gene mutations were detected in 3 (11.5%) and 14 (53.8%) patients, respectively. Conclusion: Although the most frequent cause of DM is T1D in childhood, a trend towards increase in the frequency of T2D in recent years is notable in our population.
dc.identifier.citationHaliloğlu, B., Abalı, S., Buğrul, F., Çelik, E., Baş, S., Atay, Z. ... Bereket, A. (2018). The distribution of different types of diabetes in childhood: A single center experience. Journal of Clinical Research in Pediatric Endocrinology, 10(2), 125-130. https://dx.doi.org/10.4274/jcrpe.5204
dc.identifier.doi10.4274/jcrpe.5204
dc.identifier.endpage130
dc.identifier.issn1308-5727
dc.identifier.issn1308-5735
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage125
dc.identifier.urihttps://dx.doi.org/10.4274/jcrpe.5204
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2004
dc.identifier.volume10
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Yayıncılık
dc.relation.ispartofJournal of Clinical Research in Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectType 1 Diabetes
dc.subjecttype 2 Diabetes
dc.subjectMODY
dc.subjectChildhood
dc.titleThe distribution of different types of diabetes in childhood: A single center experience
dc.typeArticle

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