Cellular protection and therapeutic potential of tocotrienols

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dc.contributor.authorÇatalgöl, Betül
dc.contributor.authorBatırel, Saime
dc.contributor.authorKartal Özer, Nesrin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:44Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:44Z
dc.date.issued2011
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.descriptionWOS: 000299624400009
dc.descriptionPubMed ID: 21774780
dc.description.abstractTocotrienols, components belonging to vitamin E members, are used as potent therapeutics in the treatment of several diseases. Recent studies suggested tocotrienol to have better activity in many situations compared to tocopherols. Tocotrienols have been shown to lower the atherogenic apolipoprotein B and lipoprotein plasma levels. Additionally, tocotrienols with their anti-tumor effect together with anti-angiogenic and anti-thrombotic effects may serve as effective agents in cancer therapy. Besides these effects, some properties such as water insolubility and low stability limit the usage of tocotrienols in the clinic. However recent studies tried to increase the bioavailability with esterification and combination use. These efforts for the clinical usage of tocotrienols which may help them to take a wide place in the clinic and additional studies are needed to identify their therapeutical mechanisms.
dc.identifier.citationÇatalgöl, B., Batırel, S. ve Kartal Özer, N. (2011). Cellular protection and therapeutic potential of tocotrienols. Current Pharmaceutical Design, 17(21), 2215-2220. https://dx.doi.org/10.2174/138161211796957436
dc.identifier.doi10.2174/138161211796957436
dc.identifier.endpage2220
dc.identifier.issn1381-6128
dc.identifier.issn1873-4286
dc.identifier.issue21
dc.identifier.scopusqualityQ1
dc.identifier.startpage2215
dc.identifier.urihttps://dx.doi.org/10.2174/138161211796957436
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2276
dc.identifier.volume17
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publishers Ltd.
dc.relation.ispartofCurrent Pharmaceutical Designen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTocotrienols
dc.subjectAtherosclerosis
dc.subjectAlzheimer's Disease
dc.subjectCancer
dc.subjectTherapy
dc.titleCellular protection and therapeutic potential of tocotrienols
dc.typeReview Article

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