Bilateral low-energy sequential femoral shaft fractures in patients on long-term bisphosphonate therapy

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dc.authorid0000-0002-7794-9308
dc.contributor.authorÇakmak, Selami
dc.contributor.authorMahiroğulları, Mahir
dc.contributor.authorKeklikçi, Kenan
dc.contributor.authorSarı, Enes
dc.contributor.authorErdik, Baran
dc.contributor.authorRodop, Osman
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:37:31Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:37:31Z
dc.date.issued2013
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalı
dc.description.abstractThe aim of this study was to evaluate the demographic characteristics of patients with bilateral bisphosphonate-related low-energy femoral shaft fractures. Methods: The clinical registry was reviewed for patients with bisphosphonate-related low-energy fractures localized at femoral shaft between January 2008 and January 2012. Patients with a diagnosis of postmenopausal osteoporosis, bisphosphonate usage of at least 5 years and prodromal pain prior to fracture were included the study. Results: Five women met the inclusion criteria. All patients had bilateral low-energy sequential femoral shaft fractures. Fracture patterns were similar and atypical (transverse-short oblique fractures with lateral cortical thickening). Mean period of bisphosphonate treatment was 8.6 years. Mean patient age was 76.2 years. Union time of three patients was between 20 and 28 weeks. The remaining two fractures were revised for delayed union or nonunion. Conclusion: Long-term (over 5 years) use of bisphosphonates may cause insufficiency fractures due to increased fragility and brittleness which have a close relationship with depressed bone remodeling. While there is still no causal relationship between bisphosphonates and atypical, low-energy femoral shaft fractures, we have some concerns about the optimal usage time and long-term safety of bisphosphonate drugs. © 2013 Turkish Association of Orthopaedics and Traumatology.
dc.identifier.citationÇakmak, S., Mahiroğulları, M., Keklikçi, K., Sarı, E., Erdik, B. ve Rodop, O. (2013). Bilateral low-energy sequential femoral shaft fractures in patients on long-term bisphosphonate therapy. Acta Orthopaedica et Traumatologica Turcica, 47(3), 162-172. https://dx.doi.org/10.3944/AOTT.2013.2934
dc.identifier.doi10.3944/AOTT.2013.2934
dc.identifier.endpage172
dc.identifier.issn1017-995X
dc.identifier.issue3
dc.identifier.scopusqualityQ2
dc.identifier.startpage162
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1420
dc.identifier.urihttps://dx.doi.org/10.3944/AOTT.2013.2934
dc.identifier.volume47
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofActa Orthopaedica et Traumatologica Turcicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAtypical Femoral Shaft Fracture
dc.subjectBisphosphonate
dc.subjectSubtrochanteric Fracture
dc.titleBilateral low-energy sequential femoral shaft fractures in patients on long-term bisphosphonate therapy
dc.typeArticle

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