Evaluation of the effect of daptomycin, a glycopeptide agent, on intact intervertebral disc tissue

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dc.authorid0000-0003-2003-6337
dc.authorid0000-0002-8084-7855
dc.contributor.authorKaplan, Necati
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorKaraaslan, Numan
dc.contributor.authorYaşar Şirin, Duygu
dc.contributor.authorŞimşek, Abdullah Talha
dc.contributor.authorÇalışkan, Tezcan
dc.contributor.authorBircan, Rıfat
dc.contributor.authorÖzbek, Hanefi
dc.date.accessioned2019-12-19T06:10:18Z
dc.date.available2019-12-19T06:10:18Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractAIM: To evaluate the effects of pre- and intra-operatively administered daptomycin (DAP) on the intact human primary intervertebral disc tissue cells. MATERIAL and METHODS: Primary cell cultures were established using tissues obtained through decompressive laminectomy, traumatic intervertebral disc herniation excision, and posterior transpedicular stabilization. Non-drug-administered samples were used as a control group. The samples treated with DAP formed the study group. Molecular assays for proliferation and gene expression were performed. The obtained data were evaluated statistically, and results with a value of p<0.05 were accepted as significant. RESULTS: While no reduction was observed in the proliferation, the gene expression of intact intervertebral disc tissue cells was time-dependently decreased compared to the control group, and these results were reported to be statistically significant. CONCLUSION: This study observed the effect that a pharmaceutical preparation, which was used on intervertebral disc tissue before and after the operation, had on normal, healthy, and intact tissue. It concludes that alterations in the expression of genes involved in the anabolic and/or catabolic process, even in adjacent healthy tissue, may slow down the healing process of the damaged tissue or cause undesired cell differentiation.
dc.identifier.citationKaplan, N., Yılmaz, İ., Karaaslan, N., Yaşar Şirin, D., Şimşek, A. T., Çalışkan, T. ... Özbek, H. (2019). Evaluation of the effect of daptomycin, a glycopeptide agent, on intact intervertebral disc tissue. Turkish Neurosurgical, 29(4), 522-529. https://doi.org/10.5137/1019-5149.JTN.24447-18.3
dc.identifier.doi10.5137/1019-5149.JTN.24447-18.3
dc.identifier.endpage529
dc.identifier.issn1019-5149
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage522
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.24447-18.3
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4528
dc.identifier.volume29
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neurosurgical Society
dc.relation.ispartofTurkish Neurosurgicalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIntervertebral Disc
dc.subjectCHAD
dc.subjectCOMP
dc.subjectDaptomycin
dc.subjectIL-1?
dc.subjectMMPs
dc.titleEvaluation of the effect of daptomycin, a glycopeptide agent, on intact intervertebral disc tissue
dc.typeArticle

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