Therapeutic applications of melatonin in disorders related to the gastrointestinal tract and control of appetite

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dc.contributor.authorFard, Atousa Moghadam
dc.contributor.authorGoodarzi, Pardis
dc.contributor.authorMottahedi, Mehran
dc.contributor.authorGarousi, Setareh
dc.contributor.authorZadabhari, Hamed
dc.contributor.authorShahijan, Mohammad Kalantari
dc.contributor.authorEsmaeili, Saeedeh
dc.contributor.authorNabi-Afjadi, Mohsen
dc.contributor.authorYousefi, Bahman
dc.date.accessioned2024-03-06T06:39:21Z
dc.date.available2024-03-06T06:39:21Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Fizyoterapi ve Rehabilitasyon Bölümü
dc.description.abstractMost animals have large amounts of the special substance melatonin, which is controlled by the light/dark cycle in the suprachiasmatic nucleus. According to what is now understood, the gastrointestinal tract (GIT) and other areas of the body are sites of melatonin production. According to recent studies, the GIT and adjacent organs depend critically on a massive amount of melatonin. Not unexpectedly, melatonin’s many biological properties, such as its antioxidant, anti-inflammatory, pro-apoptotic, anti-proliferative, anti-metastasis, and antiangiogenic properties, have drawn the attention of researchers more and more. Because melatonin is an antioxidant, it produces a lot of secretions in the GIT’s mucus and saliva, which shields cells from damage and promotes the development of certain GIT-related disorders. Melatonin’s ability to alter cellular behavior in the GIT and other associated organs, such as the liver and pancreas, is another way that it functions. This behavior alters the secretory and metabolic activities of these cells. In this review, we attempted to shed fresh light on the many roles that melatonin plays in the various regions of the gastrointestinal tract by focusing on its activities for the first time.
dc.identifier.citationFard, A. M., Goodarzi, P., Mottahedi, M., Garousi, S., Zadabhari, H., Shahijan, M. K. ... Yousefi, B. (2024). Therapeutic applications of melatonin in disorders related to the gastrointestinal tract and control of appetite. Naunyn-Schmiedeberg's Archives of Pharmacology. https://dx.doi.org/10.1007/s00210-024-02972-5
dc.identifier.doi10.1007/s00210-024-02972-5
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.pmid38358468
dc.identifier.scopus2-s2.0-85185135677
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1007/s00210-024-02972-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12339
dc.identifier.wos001162196500003en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorZadabhari, Hamed
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofNaunyn-Schmiedeberg's Archives of Pharmacologyen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectMelatonin
dc.subjectGastrointestinal Tract
dc.subjectAntioxidant
dc.subjectIBD
dc.titleTherapeutic applications of melatonin in disorders related to the gastrointestinal tract and control of appetite
dc.typeReview Article

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