Blood loss prophylaxis: Tranexamic acid is safe even in high-risk patients

The study by Porter et al. is elegant and perfectly designed. This study represents a clinically relevant and timely investigation with regard to tranexamic acid (TXA) use following hip fracture. Numerous studies have demonstrated that TXA can be considered safe and efficacious for elective total joint arthroplasty. As a result, TXA usage has gained momentum in patients undergoing arthroplasty. However, the evidence of TXA’s safety in high-risk patients with hip fracture undergoing arthroplasty is controversial. This study aimed to assess whether TXA administration to high-risk patients with hip fracture requiring arthroplasty increased the risk of thrombotic complications or mortality.