Protective effects of momordica charantia (Bitter Melon) against metho-trexate-induced kidney damage

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dc.authorid0000-0002-5532-2395
dc.contributor.authorMacit, Çağlar
dc.contributor.authorÖzbeyli, Dilek
dc.contributor.authorÇevik, Özge
dc.contributor.authorÇetin, Melisa
dc.contributor.authorŞener, Göksel
dc.contributor.authorÖzkan, Sevil
dc.date.accessioned2023-06-12T07:23:11Z
dc.date.available2023-06-12T07:23:11Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalı
dc.description.abstractBackground: Methotrexate is a cytotoxic chemotherapeutic agent that has severe side ef-fects, such as nephrotoxicity. Momordica charantia is a bright yellow-orange fruity plant that has been shown to have antioxidant, antidiabetic, and anti-inflammatory properties. Methods: 24 Sprague Dawley male rats were divided into three experimental groups (8 rats in each): Control (C); Methotrexate (MTX); and Methotrexate plus Momordica charantia (MTX+MC). All rats were fed ad libitum and tap water. Methotrexate was administered at 20 mg/kg intraperitoneally as a single dose. In the MTX+MC group, MC was administered at a dose of 50mg/kg for 5 days orally. At the end of the 5th day, the rats were decapitated and kidney samples were taken to analyze glutathione (GSH), malondialdehyde (MDA), myeloperoxidase (MPO), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and caspase-3 activity. Data was analyzed with GraphPad Prism 5.0. Results: Findings showed that while there was a significant increase in MDA, MPO, 8-OHdG levels, and an essential reduction in GSH levels in the MTX-treated group when compared with the control group, bitter melon treatment significantly reversed MDA, MPO, and 8-OHdG levels (p< 0.001). GSH level elevation was observed in the MTX-MC group when compared to the MTX-treated group (p< 0.001). Conclusion: This study showed that bitter melon is thought to have a protective effect against kidney damage caused by methotrexate. With future studies, we believe that the use of bitter melon extract as a protective agent in kidney damage caused by drug-induced oxidative damage will bring an innova-tive approach to treatment.
dc.identifier.citationMacit, Ç., Özbeyli, D., Çevik, Ö., Çetin, M., Şener, G. ve Özkan, S. (2023). Protective effects of momordica charantia (Bitter Melon) against metho-trexate-induced kidney damage. Current Drug Therapy, 18(3), 231-236. https://doi.org/10.2174/1574885518666230112110246
dc.identifier.doi10.2174/1574885518666230112110246
dc.identifier.endpage236
dc.identifier.issn1574-8855
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85160608207
dc.identifier.scopusqualityQ3
dc.identifier.startpage231
dc.identifier.urihttps://doi.org/10.2174/1574885518666230112110246
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11064
dc.identifier.volume18
dc.indekslendigikaynakScopus
dc.institutionauthorMacit, Çağlar
dc.language.isoen
dc.publisherBentham Science Publishers
dc.relation.ispartofCurrent Drug Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectKidney
dc.subjectMethotrexate
dc.subjectMomordica Charantia
dc.subjectNephrotoxicity
dc.subjectOxidative Damage
dc.subjectProtective Effect
dc.titleProtective effects of momordica charantia (Bitter Melon) against metho-trexate-induced kidney damage
dc.typeArticle

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