Optimizing outcomes in heart transplantation: the role of high-intensity statin therapy

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dc.contributor.authorGhavamikia, Nima
dc.contributor.authorSaffarfar, Hossein
dc.contributor.authorSeifdavati, Babak
dc.contributor.authorJamali, Mohaddeseh
dc.contributor.authorIzadidehkordi, Shadi
dc.contributor.authorPakmehr, Seyyed Abbas
dc.contributor.authorShahhoseini, Reza
dc.date.accessioned2025-11-21T08:29:15Z
dc.date.available2025-11-21T08:29:15Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi
dc.description.abstractHeart transplantation is a vital procedure for patients with end-stage heart failure, but it faces significant challenges, including graft dysfunction, rejection, and cardiac allograft vasculopathy (CAV), which can compromise long-term graft success. Research suggests that statin therapy may offer significant benefits to heart transplant recipients, such as improved long-term survival and reduced rates of graft rejection and mortality. The aim of this review is to thoroughly examine the recent literature on this topic since 2005. Early use of high-dose statins appears to be particularly effective in preventing vasculopathy and improving outcomes, although a titrated approach may help to reduce side effects. High-dose statins may provide superior cardiovascular benefits, including lower rates of CVD, slower progression of CVD and improved long-term graft survival. Despite potential concerns about adverse effects, evidence suggests that high-intensity statins improve cholesterol levels without increasing serious adverse events after transplantation. The goal of statin therapy in heart transplant recipients is to balance the well-established benefits seen in the general population with the specific needs of this group, with the ultimate goal of improving both longevity and quality of life.
dc.identifier.citationGhavamikia, N., Saffarfar, H., Seifdavati, B., Jamali, M., Izadidehkordi, S., Pakmehr, S. A. ... Shahhoseini, R. (2024). Optimizing outcomes in heart transplantation: the role of high-intensity statin therapy. Journal of Biochemical and Molecular Toxicology, 38(12). http://dx.doi.org/10.1002/jbt.70070
dc.identifier.doi10.1002/jbt.70070
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue12
dc.identifier.pmid39601209
dc.identifier.scopus2-s2.0-85210523250
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.1002/jbt.70070
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13228
dc.identifier.volume38
dc.identifier.wosWOS:001370284700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorShahhoseini, Reza
dc.language.isoen
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryDiÄŸer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCoronary Allograft Vasculopathy
dc.subjectGraft Rejection
dc.subjectHeart Transplantation
dc.subjectHigh-Intensity Statins
dc.subjectStatin Therapy
dc.titleOptimizing outcomes in heart transplantation: the role of high-intensity statin therapy
dc.typeOther

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