Inherited transmission of the CSF3R T618I mutation: A familial report

To the editor, Chronic neutrophilic leukemia (CNL) is a rare, break cluster region-Abelson 1 (BCR-ABL1) negative myeloproliferative neoplasm, which is characterized by mature neutrophilic proliferation with neutrophilic hyperplasia in bone marrow and hepatosplenomegaly [1]. The disease is frequently diagnosed at an advanced age; therefore, the median age of diagnosis was reported as 66.5 [2]. There are a few features that distinguish CNL from chronic myeloid leukemia (CML), such as more mature granulopoietic forms compared to CML, the preponderance of granulocytes (??80%) at the segmented or band stage of maturation, and minimal to no circulating blasts [1, 2]. Deterioration of thrombocytopenia along with increasing splenomegaly points out disease progression or blastic crisis [2].