Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers

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dc.authorid0000-0002-4375-2881
dc.contributor.authorElmas, Bahri
dc.contributor.authorKaracan, Mehmet
dc.contributor.authorDervişoğlu, Pınar
dc.contributor.authorKösecik, Mustafa
dc.contributor.authorİşgüven, Şükriye Pınar
dc.contributor.authorBal, Ceylan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:37:03Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:37:03Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: Childhood obesity is an important cause of cardiovascular risk with chronic inflammation. Oxidative stress may contribute to the pathogenesis of obesity-related cardiovascular pathologies. We aimed to evaluate thiol/disulphide homeostasis as a novel and sensitive marker of oxidative stress and to evaluate its relationship with some inflammatory and cardiovascular markers in obese children. Methods: In this case-controlled study, 65 children with exogenous obesity and 64 healthy children, as a control group, were included. In both groups, thiol/disulphide homeostasis parameters and inflammatory (white blood cells, platelets, mean corpuscular volume, neutrophil/lympho-cyte ratio, and high-sensitivity C-reactive protein) and cardiovascular (epicardial adipose tissue thickness and left ventricular mass index) markers were studied. Correlation analyses of thiol/disulphide homeostasis parameters with body mass index standard deviation scores (BMI SDS) and inflammatory and cardiovascular markers were performed. Receiver-operating characteristic analysis was performed to determine the sensitivity, specificity, and optimal cut-off values of thiol/disulphide homeostasis parameters. Results: Native thiol, total thiol, and native thiol/total thiol ratios (antioxidant parameters) were lower (p<0.05) and disulphide/native thiol and disulphide/total thiol ratios (oxidant parameters) were higher in the obese group than in the control group (p<0.01). A positive correlation of oxidant parameters with BMI SDS and inflammatory markers was found. However, a negative correlation of antioxidant parameters with BMI SDS and inflammatory markers was found. The specificities of disulphide/native thiol and disulphide/total thiol ratios were higher in the obese group. Conclusion: The impairment in thiol/disulphide homeostasis, which is indicative of oxidative stress, is associated with inflammation in obesity. In addition, cardiovascular involvement may also contribute to this impairment.
dc.identifier.citationElmas, B., Karacan, M., Dervişoğlu, P., Kösecik, M., İşgüven, Ş. P. ve Bal, C. (2017). Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers. Anatolian Journal of Cardiology, 18(5), 361-369. https://dx.doi.org/10.14744/AnatolJCardiol.2017.7740
dc.identifier.doi10.14744/AnatolJCardiol.2017.7740
dc.identifier.endpage369
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue5
dc.identifier.scopusqualityQ3
dc.identifier.startpage361
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1320
dc.identifier.urihttps://dx.doi.org/10.14744/AnatolJCardiol.2017.7740
dc.identifier.volume18
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Society of Cardiology
dc.relation.ispartofAnatolian Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCardiovascular Risk
dc.subjectChildren
dc.subjectInflammation
dc.subjectObesity
dc.subjectOxidative Stress
dc.subjectThiol/Disulphide Homeostasis
dc.titleDynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers
dc.typeArticle

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