Protective effects of momordica charantia (Bitter Melon) against methotrexate-induced kidney damage

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dc.authorid0000-0002-5532-2395
dc.contributor.authorMacit, Çağlar
dc.contributor.authorÖzbeyli, Dilek
dc.contributor.authorÇevik, Özge
dc.contributor.authorÇetin, Melisa
dc.contributor.authorŞener, Göksel
dc.contributor.authorÖzkan, Sevil
dc.date.accessioned2023-07-20T09:08:19Z
dc.date.available2023-07-20T09:08:19Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalı
dc.description.abstractBackground Methotrexate is a cytotoxic chemotherapeutic agent that has severe side effects, such as nephrotoxicity. Momordica charantia is a bright yellow-orange fruity plant that has been shown to have antioxidant, antidiabetic, and anti-inflammatory properties. Objective This study scrutinized the protective effects of Momordica charantia extract against methotrexate-induced nephrotoxicity. Methods 24 Sprague Dawley male rats were divided into three experimental groups (8 rats in each): Control (C); Methotrexate (MTX); and Methotrexate plus Momordica charantia (MTX+MC). All rats were fed ad libitum and tap water. Methotrexate was administered at 20 mg/kg intraperitoneally as a single dose. In the MTX+MC group, MC was administered at a dose of 50mg/kg for 5 days orally. At the end of the 5th day, the rats were decapitated and kidney samples were taken to analyze glutathione (GSH), malondialdehyde (MDA), myeloperoxidase (MPO), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and caspase-3 activity. Data was analyzed with GraphPad Prism 5.0. Results Findings showed that while there was a significant increase in MDA, MPO, 8-OHdG levels, and an essential reduction in GSH levels in the MTX-treated group when compared with the control group, bitter melon treatment significantly reversed MDA, MPO, and 8-OHdG levels (p< 0.001). GSH level elevation was observed in the MTX-MC group when compared to the MTX-treated group (p< 0.001). Conclusion This study showed that bitter melon is thought to have a protective effect against kidney damage caused by methotrexate. With future studies, we believe that the use of bitter melon extract as a protective agent in kidney damage caused by drug-induced oxidative damage will bring an innovative approach to treatment.
dc.identifier.citationMacit, Ç., Özbeyli, D., Çevik, Ö., Çetin, M., Şener, G. ve Özkan, S. (2023). Protective effects of momordica charantia (Bitter Melon) against methotrexate-induced kidney damage. Current Drug Therapy, 18(3), 231-236. https://dx.doi.org/10.2174/1574885518666230112110246
dc.identifier.doi10.2174/1574885518666230112110246
dc.identifier.endpage236
dc.identifier.issn1574-8855
dc.identifier.issn2212-3903
dc.identifier.issue3
dc.identifier.startpage231
dc.identifier.urihttps://dx.doi.org/10.2174/1574885518666230112110246
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11227
dc.identifier.volume18
dc.identifier.wos001016603900006en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorMacit, Çağlar
dc.language.isoen
dc.publisherBentham Science Publishers Ltd.
dc.relation.ispartofCurrent Drug Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMomordica Charantia
dc.subjectKidney
dc.subjectMethotrexate
dc.subjectNephrotoxicity
dc.subjectOxidative Damage
dc.subjectProtective Effect
dc.titleProtective effects of momordica charantia (Bitter Melon) against methotrexate-induced kidney damage
dc.typeArticle

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