The renaissance of male infertility management in the golden age of andrology

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dc.authorid0000-0002-9976-9666
dc.contributor.authorCalogero, Aldo E.
dc.contributor.authorCannarella, Rossella
dc.contributor.authorAgarwal, Ashok
dc.contributor.authorHamoda, Taha Abo-Almagd Abdel-Meguid
dc.contributor.authorRambhatla, Amarnath
dc.contributor.authorSaleh, Ramadan
dc.contributor.authorBoitrelle, Florence
dc.contributor.authorZiouziou, Imad
dc.contributor.authorToprak, Tuncay
dc.contributor.authorGül, Murat
dc.contributor.authorAvidor-Reiss, Tomer
dc.contributor.authorKavoussi, Parviz
dc.contributor.authorChung, Eric
dc.contributor.authorBirowo, Ponco
dc.contributor.authorGhayda, Ramy Abou
dc.contributor.authorKo, Edmund
dc.contributor.authorColpi, Giovanni
dc.contributor.authorDimitriadis, Fotios
dc.contributor.authorRusso, Giorgio Ivan
dc.contributor.authorMartinez, Marlon
dc.contributor.authorÇalik, Gökhan
dc.contributor.authorKandil, Hussein
dc.contributor.authorSalvio, Gianmaria
dc.contributor.authorMostafa, Taymour
dc.contributor.authorLin, Haocheng
dc.contributor.authorPark, Hyun Jun
dc.contributor.authorGherabi, Nazim
dc.contributor.authorPhuoc, Nguyen Ho Vinh
dc.contributor.authorQuang, Nguyen
dc.contributor.authorAdriansjah, Ricky
dc.contributor.authorLa Vignera, Sandro
dc.contributor.authorMicic, Sava
dc.contributor.authorDurairajanayagam, Damayanthi
dc.contributor.authorŞerefoglu, Ege Can
dc.contributor.authorKarthikeyan, Vilvapathy Senguttuvan
dc.contributor.authorKothari, Priyank
dc.contributor.authorAtmoko, Widi
dc.contributor.authorShah, Rupin
dc.date.accessioned2023-05-23T13:52:12Z
dc.date.available2023-05-23T13:52:12Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractInfertility affects nearly 186 million people worldwide and the male partner is the cause in about half of the cases. Meta-regression data indicate an unexplained decline in sperm concentration and total sperm count over the last four decades, with an increasing prevalence of male infertility. This suggests an urgent need to implement further basic and clinical research in Andrology. Andrology developed as a branch of urology, gynecology, endocrinology, and, dermatology. The first scientific journal devoted to andrological sciences was founded in 1969. Since then, despite great advancements, andrology has encountered several obstacles in its growth. In fact, for cultural reasons, the male partner has often been neglected in the diagnostic and therapeutic workup of the infertile couple. Furthermore, the development of assisted reproductive techniques (ART) has driven a strong impression that this biotechnology can overcome all forms of infertility, with a common belief that having a spermatozoon from a male partner (a sort of sperm donor) is all that is needed to achieve pregnancy. However, clinical practice has shown that the quality of the male gamete is important for a successful ART outcome. Furthermore, the safety of ART has been questioned because of the high prevalence of comorbidities in the offspring of ART conceptions compared to spontaneous conceptions. These issues have paved the way for more research and a greater understanding of the mechanisms of spermatogenesis and male infertility. Consequently, numerous discoveries have been made in the field of andrology, ranging from genetics to several "omics"technologies, oxidative stress and sperm DNA fragmentation, the sixth edition of the WHO manual, artificial intelligence, management of azoospermia, fertility in cancers survivors, artificial testis, 3D printing, gene engineering, stem cells therapy for spermatogenesis, and reconstructive microsurgery and seminal microbiome. Nevertheless, as many cases of male infertility remain idiopathic, further studies are required to improve the clinical management of infertile males. A multidisciplinary strategy involving both clinicians and scientists in basic, translational, and clinical research is the core principle that will allow andrology to overcome its limits and reach further goals. This state-of-the-art article aims to present a historical review of andrology, and, particularly, male infertility, from its "Middle Ages"to its "Renaissance", a golden age of andrology.
dc.identifier.citationCalogero, Aldo E., Cannarella, R., Agarwal, A., Hamoda, T. A.-A. A.-M., Rambhatla, A., Saleh, Ramadan ... Shah, R. (2023). The renaissance of male infertility management in the golden age of andrology. World Journal of Men's Health, 41(2), 237-254. https://doi.org/10.5534/wjmh.220213
dc.identifier.doi10.5534/wjmh.220213
dc.identifier.endpage254
dc.identifier.issn2287-4208
dc.identifier.issn2287-4690
dc.identifier.issue2
dc.identifier.pmid36649928
dc.identifier.scopus2-s2.0-85154562574
dc.identifier.scopusqualityQ1
dc.identifier.startpage237
dc.identifier.urihttps://doi.org/10.5534/wjmh.220213
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10959
dc.identifier.volume41
dc.identifier.wos000923261800001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇalık, Gökhan
dc.language.isoen
dc.publisherKorean Society for Sexual Medicine and Andrology
dc.relation.ispartofWorld Journal of Men's Healthen_US
dc.relation.publicationcategoryDiğer
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectAndrology
dc.subjectMale Infertility
dc.subjectSpermatozoa
dc.titleThe renaissance of male infertility management in the golden age of andrology
dc.typeOther

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