Covid-19: Pathogenesis, genetic polymorphism, clinical features and laboratory findings

Öztürk, Recep; Taşova, Yeşim; Ayaz, Akif

Covid-19: Pathogenesis, genetic polymorphism, clinical features and laboratory findings

dc.authorid	0000-0002-2623-7212
dc.authorid	0000-0001-6930-7148
dc.contributor.author	Öztürk, Recep
dc.contributor.author	Taşova, Yeşim
dc.contributor.author	Ayaz, Akif
dc.date.accessioned	2020-12-22T06:56:48Z
dc.date.available	2020-12-22T06:56:48Z
dc.date.issued	2020
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalı
dc.description.abstract	COVID-19 caused by a novel agent SARS-CoV-2 progressed to a pandemic condition and resulted in a major public health concern worldwide, leading to social and economic issues at the same time. The pathogenesis of COVID-19 starts with the bonding of the virus to ACE2 receptors expressed in many tissues, and the triggered excessive immune response plays a critical role in the course of the disease. The cytokine storm that occurs upon excessive production of pro-inflammatory cytokines is considered responsible for the severe progression of the disease and the organ damage. However, the accurate pathophysiological mechanism of the disease, which progresses with various clinical presentations, is still substantially unknown. While various studies have been conducted on the effect of genetic polymorphism on the course and severity of the disease, the presence of a significant effect has not been proven yet. The clinical course of the disease is variable, with clinical representation ranging from 81% mild course to 14% severe course along with 5% critical course in patients. Asymptomatic course is considered to be higher than expected, although its frequency is not known exactly. Older adults and those with comorbidities are exposed to a more severe disease course. The disease progress with various symptoms, such as fever, cough, dyspnea, malaise, myalgia, taste and smell dysfunctions, diarrhea, and headache. A range of complications (acute respiratory distress syndrome, thromboembolic conditions, arrhythmia and cardiac events, secondary infections) could be seen during the course of the disease. Varied laboratory tests are vital to determine these verity and prognosis of the disease, along with the condition and exposure of the affected systems during thecourse of COVID-19.
dc.identifier.citation	Öztürk, R., Taşova, Y. ve Ayaz, A. (2020). Covid-19: Pathogenesis, genetic polymorphism, clinical features and laboratory findings. Turkish Journal of Medical Sciences, 50(SI-1), 638-657. https://dx.doi.org/10.3906/SAG-2005-287
dc.identifier.doi	10.3906/SAG-2005-287
dc.identifier.endpage	657
dc.identifier.issn	1300-0144
dc.identifier.issn	1303-6165
dc.identifier.issue	SI-1
dc.identifier.scopusquality	Q3
dc.identifier.startpage	638
dc.identifier.uri	https://dx.doi.org/10.3906/SAG-2005-287
dc.identifier.uri	https://hdl.handle.net/20.500.12511/6122
dc.identifier.volume	50
dc.identifier.wosquality	Q4
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.indekslendigikaynak	PubMed
dc.language.iso	en
dc.publisher	TUBITAK Scientific & Technological Research Council of Turkey
dc.relation.ispartof	Turkish Journal of Medical Sciences	en_US
dc.relation.publicationcategory	Diğer
dc.rights	Attribution 4.0 International	*
dc.rights	info:eu-repo/semantics/openAccess
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject	Clinical Features
dc.subject	COVID-19
dc.subject	Genetic Polymorphism
dc.subject	Laboratory Findings
dc.subject	Pathogenesis
dc.subject	SARS-CoV-2
dc.title	Covid-19: Pathogenesis, genetic polymorphism, clinical features and laboratory findings
dc.type	Review Article