Hepatocellular carcinomas with granulomatous inflammation in tumor stroma: Clinicopathologic characteristics

Saka, Burcu; Özden, Ferhat; Armutlu, Ayşe; Ertuğrul, Gökhan

Hepatocellular carcinomas with granulomatous inflammation in tumor stroma: Clinicopathologic characteristics

dc.authorid	0000-0001-6830-7701
dc.authorid	0000-0002-2901-4671
dc.authorid	0000-0002-8351-4220
dc.contributor.author	Saka, Burcu
dc.contributor.author	Özden, Ferhat
dc.contributor.author	Armutlu, Ayşe
dc.contributor.author	Ertuğrul, Gökhan
dc.date.accessioned	2022-06-02T12:43:22Z
dc.date.available	2022-06-02T12:43:22Z
dc.date.issued	2022
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstract	Objective: To determine the frequency of granulomatous inflammation within hepatocellular carcinoma (HCC) and its clinicopathologic associations. Material and Method: Fifty-eight HCCs (51 explants, 3 lobectomies, and 4 segmentectomies) were reviewed. Results: Five (8.6%) cases (F/M=1/4, mean age: 63.6) were identified with granulomas.1/5 had history of neoadjuvant therapy. 4/5 patients presented with early stage (pT1/2). All were well-differentiated (Grade1-2/4). The mean number of tumor foci was 3.6, with a median size of 2.2 cm. All of them had advanced fibrosis. No difference was identified from cases without granulomas (n=53) in terms of prognosis and aforementioned parameters (p> 0.05). Granulomas were mainly concentrated in peripheral parts of the tumors. One case with nodule-in-nodule formation had granulomas lined along the border of the inner nodule. In 2 cases, granulomas were identified in steatohepatitic areas, while another had clear cell change. Only 1 had necrotizing granulomas, none with acid resistant bacilli. Two cases revealed concomitant granulomas in the adjacent liver parenchyma in addition to the tumor stroma. Except for one with a history of tuberculosis, none of the cases had a granulomatous disease. Conclusion: This is the largest case series of HCCs with granulomas by far. Our data revealed neither clinicopathologic and prognostic difference nor definite etiology related to granulomas. Yet, association with steatotic and clear tumor cells suggests the role of cytoplasmic content, while distribution of granulomas points to host immune response.
dc.identifier.citation	Saka, B., Özden, F., Armutlu, A. ve Ertuğrul, G. (2022). Hepatocellular carcinomas with granulomatous inflammation in tumor stroma: Clinicopathologic characteristics. Turkish Journal of Pathology, 38(2), 133-141. https://doi.org/10.5146/tjpath.2021.01562
dc.identifier.doi	10.5146/tjpath.2021.01562
dc.identifier.endpage	141
dc.identifier.issn	1018-5615
dc.identifier.issn	1309-5730
dc.identifier.issue	2
dc.identifier.pmid	34757621
dc.identifier.scopus	2-s2.0-85130637233
dc.identifier.scopusquality	Q3
dc.identifier.startpage	133
dc.identifier.trdizinid	527151
dc.identifier.uri	https://doi.org/10.5146/tjpath.2021.01562
dc.identifier.uri	https://hdl.handle.net/20.500.12511/9487
dc.identifier.volume	38
dc.identifier.wos	000798499800008	en_US
dc.identifier.wosquality	N/A
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.indekslendigikaynak	TR-Dizin
dc.indekslendigikaynak	PubMed
dc.institutionauthor	Saka, Burcu
dc.institutionauthor	Özden, Ferhat
dc.institutionauthor	Ertuğrul, Gökhan
dc.language.iso	en
dc.publisher	Federation of Turkish Pathology Societies
dc.relation.ispartof	Turkish Journal of Pathology	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Hepatocellular Carcinoma
dc.subject	Inflammation
dc.subject	Granuloma
dc.title	Hepatocellular carcinomas with granulomatous inflammation in tumor stroma: Clinicopathologic characteristics
dc.type	Article