Topical application of cyclosporine reduces epineurial fibrosis: Gross post-surgical, histopathological and ultrastructural analysis in a rat sciatic nerve model

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dc.contributor.authorÇetinalp, Nuri Eralp
dc.contributor.authorAlbayrak, Serdar Baki
dc.contributor.authorİsmailoğlu, Özgür
dc.contributor.authorTemiz, Nail Çağlar
dc.contributor.authorSolmaz, İlker
dc.contributor.authorTanrıöver, Gamze
dc.contributor.authorDemir, Necdet
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:04:12Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:04:12Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.descriptionWOS: 000417623700017
dc.description.abstractAIM: To investigate the anti-scarring potential of topical cyclosporine on rat sciatic nerves. MATERIAL and METHODS: Both sciatic nerves were exposed in 24 adult male albino Wistar rats, and an abrasion injury was made on the biceps femoris close to the sciatic nerve. Cotton pads soaked with cyclosporine (5 mg/mL) and saline (0.9% NaCl) were placed around the nerves for 10 minutes in the experimental group and control group, respectively. All rats were sacrificed 8 weeks later and the sciatic nerves were examined. Epineurial adhesions were assessed using light and electron microscopy. Quantitative histological parameters, epineurial thickness, and scar density were evaluated in the histological investigation. RESULTS: Significantly fewer epineurial adhesions were observed in the cyclosporine group in the post-surgical assessment, and the histopathological and ultrastructural examinations of the nerve segments than in the controls. The cyclosporine- treated animals had a statistically significant reduction in the density and quantity of epineurial scarring compared with the controls. CONCLUSION: Topical cyclosporine effectively reduces epineurial scar formation on rat sciatic nerves.
dc.identifier.citationÇetinalp, N. E., Albayrak, S. B., İsmailoğlu, Ö., Temiz, N. Ç., Solmaz, İ., Tanrıöver, G. ... Demir, N. (2017). Topical application of cyclosporine reduces epineurial fibrosis: Gross post-surgical, histopathological and ultrastructural analysis in a rat sciatic nerve model. Turkish Neurosurgery, 27(6), 969-974. https://dx.doi.org/10.5137/1019-5149.JTN.17871-16.1
dc.identifier.doi10.5137/1019-5149.JTN.17871-16.1
dc.identifier.endpage974
dc.identifier.issn1019-5149
dc.identifier.issue6
dc.identifier.scopusqualityQ3
dc.identifier.startpage969
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.17871-16.1
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4014
dc.identifier.volume27
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTurkish Neurosurgical Soc
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCyclosporine
dc.subjectSciatic Nerve
dc.subjectEpineurial Fibrosis
dc.subjectRat
dc.titleTopical application of cyclosporine reduces epineurial fibrosis: Gross post-surgical, histopathological and ultrastructural analysis in a rat sciatic nerve model
dc.typeArticle

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