Quality by design approach for optimizing preparation and characterization of buccal film formulation with different polymers

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dc.contributor.authorAksu, Buket
dc.contributor.authorCoşkunmeriç, Nesrin
dc.contributor.authorYeğen, Gizem
dc.contributor.authorÖzalp, Yıldız
dc.contributor.authorÜstündağ Okur, Neslihan
dc.date.accessioned2020-03-20T11:12:48Z
dc.date.available2020-03-20T11:12:48Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractBilayered oromucosal film preparations (buccal films) offer a promising way to enable drug administration via the oral cavity. Polymeric film formulations containing chitosan, sodium alginate or carbopol were evaluated to select a formulation for the development of buccal drug delivery systems. Quality by Design (QbD) is increasingly becoming an important and widely used approach in the pharmaceutical industry. QbD requires producing an understanding of the critical variables affecting the attribues of products. In this study, the principles of QbD have been uniquely applied to 54 different kinds of film formulation contain different excipients as Chitosan, Carbopol, Sodium Alginate, Glycerine, PEG 400, Propylene Glycol to obtain appropriate buccal formulations. Each of the prepared formulations contains different ingredients combination and ingredients’ ratio (% w/v), which appear changes. For this aim, to evaluate the effects of variables to the film formulations, they were characterized as thickness, weight uniformity, swelling and moisture loss.
dc.identifier.citationAksu, B., Coşkunmeriç, N., Yeğen, G., Özalp, Y. ve Üstündağ Okur, N. (2019). Quality by design approach for optimizing preparation and characterization of buccal film formulation with different polymers. International Journal of Pharmaceutical Research, 11(Supplementary: 1), 1153-1160. https://doi.org/10.31838/ijpr/2019.11.05.002
dc.identifier.doi10.31838/ijpr/2019.11.05.002
dc.identifier.endpage1160
dc.identifier.issn0975-2366
dc.identifier.issueSupplementary: 1
dc.identifier.scopusqualityQ2
dc.identifier.startpage1153
dc.identifier.urihttps://doi.org/10.31838/ijpr/2019.11.05.002
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5050
dc.identifier.volume11
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAdvanced Scientific Research
dc.relation.ispartofInternational Journal of Pharmaceutical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBuccal Drug Delivery
dc.subjectFilm
dc.subjectQuality By Design
dc.titleQuality by design approach for optimizing preparation and characterization of buccal film formulation with different polymers
dc.typeArticle

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