B cells and progressive multifocal leukoencephalopathy: Search for the missing link

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dc.contributor.authorDurali, Deniz
dc.contributor.authorde Herve, Marie-Ghislaine de Goer
dc.contributor.authorGasnault, Jacques
dc.contributor.authorTaoufik, Yassine
dc.contributor.editorLovett-Racke, Amy
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:02Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:02Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000355324600001
dc.descriptionPubMed ID: 26042124
dc.description.abstractProgressive multifocal leukoencephalopathy (PML) is a deadly demyelinating disease due to JC virus (JCV) replication in the brain. PML classically occurs in patients with severe immunodepression, and cases have recently been linked to therapeutic monoclonal antibodies such as natalizumab and also rituximab, which depletes B cells. B cells appear to play a complex role in the pathogenesis of PML. They may act as a viral reservoir and as a vector for viral dissemination in the central nervous system. Anti-JCV antibody responses appear to have a limited effect on JCV replication in the brain. However, accumulating evidence suggests that B cells may considerably influence T cell responses through their cytokine secretion. This immunomodulatory function of B cells may play an important role in the control of JCV infection and in the pathogenesis of PML, including rituximab-induced PML.
dc.identifier.citationDurali, D., de Herve, M., Gasnault, J. ve Taoufik, Y. (2015). B cells and progressive multifocal leukoencephalopathy: Search for the missing link. Frontiers in Immunology, 6, 241. https://dx.doi.org/10.3389/fimmu.2015.00241
dc.identifier.doi10.3389/fimmu.2015.00241
dc.identifier.issn1664-3224
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.3389/fimmu.2015.00241
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2541
dc.identifier.volume6
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFrontiers Media
dc.relation.ispartofFrontiers in Immunologyen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectprogressive Multifocal Leukoencephalopathy
dc.subjectJC Virus
dc.subjectB Cells
dc.subjectImmune Regulation
dc.subjectT Cells
dc.titleB cells and progressive multifocal leukoencephalopathy: Search for the missing link
dc.typeReview Article

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