New 8-heterocyclic xanthine derivatives as antiproliferative agents: Synthesis and biological evaluation

Sucu, Bilgesu Onur

New 8-heterocyclic xanthine derivatives as antiproliferative agents: Synthesis and biological evaluation

dc.authorid	0000-0003-0957-6965
dc.contributor.author	Sucu, Bilgesu Onur
dc.date.accessioned	2024-06-24T12:33:51Z
dc.date.available	2024-06-24T12:33:51Z
dc.date.issued	2024
dc.department	İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.department	İstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.description.abstract	This research focuses on the synthesis, characterization, and evaluation of the anti-cancer activity of novel 8-aryl substituted 1,3-diethylxanthine derivatives. The anti-proliferative activities of all the compounds were assessed using an MTT assay on four human cancer cell lines: breast cancer MCF7, human lung cancer A549, human brain cancers LN229, and U87. One of the derivatives of 1,3-diethylxanthine with a thiazole structure displayed strong anti-proliferative activity. 1,3-Diethyl-8-(thiazol-4-yl)-3,7-dihydro-1H-purine-2,6-dione (5) exhibited the strongest activity against A549, MCF7, LN229, and U87 cell lines, with IC50 values of 16.70, 78.06, 22.07, and 25.07 ?M, respectively. Furthermore, the scratch assay was conducted to evaluate the effect of compound 5 on the inhibition of cell migration in A549 cells. The consistent results demonstrate that compound 5 exhibits potent anticancer activity, which could be further investigated to enhance its biological potential.
dc.identifier.citation	Sucu, B. O. (2024). New 8-heterocyclic xanthine derivatives as antiproliferative agents: Synthesis and biological evaluation. Journal of the Turkish Chemical Society, Section A: Chemistry, 11(2), 517-526. http://dx.doi.org/10.18596/jotcsa.1340105
dc.identifier.doi	10.18596/jotcsa.1340105
dc.identifier.endpage	526
dc.identifier.issn	2149-0120
dc.identifier.issue	2
dc.identifier.scopus	2-s2.0-85195116975
dc.identifier.scopusquality	Q3
dc.identifier.startpage	517
dc.identifier.uri	http://dx.doi.org/10.18596/jotcsa.1340105
dc.identifier.uri	https://hdl.handle.net/20.500.12511/12643
dc.identifier.volume	11
dc.indekslendigikaynak	Scopus
dc.institutionauthor	Sucu, Bilgesu Onur
dc.language.iso	en
dc.relation.ispartof	Journal of the Turkish Chemical Society, Section A: Chemistry	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Anti-Cancer
dc.subject	Antiproliferative Activity
dc.subject	Heterocyclic Compounds
dc.subject	MTT
dc.subject	Xanthine
dc.title	New 8-heterocyclic xanthine derivatives as antiproliferative agents: Synthesis and biological evaluation
dc.type	Article