Importance of physiological oxygen levels for endothelial redox signaling using Hyper 7

Basit Öğe Kaydı
dc.authorid0000-0002-9373-0808
dc.contributor.authorAltun, Hamza Yusuf
dc.contributor.authorYang, Fan
dc.contributor.authorMann, Giovanni
dc.contributor.authorEroğlu, Emrah
dc.date.accessioned2023-12-29T09:56:35Z
dc.date.available2023-12-29T09:56:35Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.description.abstractCellular redox status is tightly linked to ambient oxygen levels. Endothelial cells (EC) in vivo are exposed to O2 levels between 3- 13 kPa, yet the majority in vitro studies maintain EC under atmospheric O2 levels (~18 O2). Under 18 kPa O2, EC are exposed to hyperoxia, leading to persistent upregulation of NRF2 regulated antioxidant defences. Exposure of EC to physiological O2 levels for at least 5 days attenuates NRF2-regulated antioxidant gene expression in the absence of HIF-1a stabilisation.
dc.description.sponsorshipCA20121en_US
dc.identifier.citationAltun, H. Y., Yang, F., Mann, G. ve Eroğlu, E. (2023). Importance of physiological oxygen levels for endothelial redox signaling using Hyper 7. Free Radical Biology and Medicine içinde (S8-S9. ss.). Punta del Este, Uruguay, 15-18 November, 2023. https://dx.doi.org/10.1016/j.freeradbiomed.2023.10.018
dc.identifier.doi10.1016/j.freeradbiomed.2023.10.018
dc.identifier.endpageS9
dc.identifier.issn0891-5849
dc.identifier.issn1873-4596
dc.identifier.issueSupplement: 1
dc.identifier.startpageS8
dc.identifier.urihttps://dx.doi.org/10.1016/j.freeradbiomed.2023.10.018
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12077
dc.identifier.volume208
dc.identifier.wos001098825800009en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.institutionauthorEroğlu, Emrah
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofFree Radical Biology and Medicineen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectHyper 7
dc.subjectEndothelial Redox Signaling
dc.subjectOxygen Levels
dc.titleImportance of physiological oxygen levels for endothelial redox signaling using Hyper 7
dc.typeConference Object

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