Predictive factor for lymph node metastasis in non-metastatic colorectal adenocarcinomas

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dc.contributor.authorKarcı, Ebru
dc.contributor.authorÜrün, Yüksel
dc.contributor.authorKöksoy, Elif Berna
dc.contributor.authorUçar, Gökhan
dc.contributor.authorBilgin, Burak
dc.contributor.authorYekedüz, Emre
dc.contributor.authorArslan, Çağatay
dc.contributor.authorAlkan, Ali
dc.contributor.authorDede, İsa
dc.contributor.authorTuncay, Gülseren
dc.contributor.authorHocazade, Cemil
dc.contributor.authorYıldırım Özdemir, Nuriye
dc.contributor.authorŞendur, Mehmet Ali Nahit
dc.contributor.authorUtkan, Güngör
dc.contributor.authorYalçın, Bülent
dc.contributor.authorAkbulut, Hakan
dc.date.accessioned2023-08-29T08:42:01Z
dc.date.available2023-08-29T08:42:01Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjectives: To evaluate the predictive factors of lymph node involvement in non-metastatic colorectal adenocarcinomas (nmCRC). Methods: A total of 453 patients diagnosed with nmCRC were analyzed regarding T stage, lymphovascular invasion status, tumor grade and proposed risk score (RS), determined by the combination of these three factors for lymph node metastasis. Results: The median age was 62 (25-90 years), M/F ratio was 1.4:1 and majority of the patients had tumors localized on the left colon (70.6%). The number of excised lymph nodes was ?12 in 77% of the cases. The postoperative pathological assessments revealed that 57.2% of patie,nts had N0 disease, 29.1% had N1 disease, and 13.7% had N2 disease. The T stages (p=0.007), grade (p<0.001), lymphovascular invasion (p=0.002), RS (p<0.001), and number of excised lymph nodes (p=0.029) were significantly different between N0, N1, and N2 patients. Higher RS was associated with lymph node metastasis (p<0.001). Conclusion: The risk score may predict lymph node metastasis in patients with nmCRC and if validated may be helpful in the decision-making of adjuvant chemotherapy, especially in the elderly and patients with inadequate lymph node dissection.
dc.identifier.citationKarcı, E., Ürün, Y., Köksoy, E. B., Uçar, G., Bilgin, B., Yekedüz, E. ... Akbulut, H. (2022). Predictive factor for lymph node metastasis in non-metastatic colorectal adenocarcinomas. Eurasian Journal of Medical Investigation, 6(3), 279-283. https://dx.doi.org/10.14744/ejmi.2022.37065
dc.identifier.doi10.14744/ejmi.2022.37065
dc.identifier.endpage283
dc.identifier.issn2602-3164
dc.identifier.issue3
dc.identifier.startpage279
dc.identifier.trdizinid1133889
dc.identifier.urihttps://dx.doi.org/10.14744/ejmi.2022.37065
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11374
dc.identifier.volume6
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorKarcı, Ebru
dc.language.isoen
dc.publisherKare Publishing
dc.relation.ispartofEurasian Journal of Medical Investigationen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectColorectal Adenocarcinomas
dc.subjectLymph Node Metastasis
dc.subjectPredictive Factor
dc.titlePredictive factor for lymph node metastasis in non-metastatic colorectal adenocarcinomas
dc.typeArticle

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