Headache onset after vaccination against SARS-CoV-2: A systematic literature review and meta-analysis

Basit Öğe Kaydı
dc.contributor.authorCastaldo, Matteo
dc.contributor.authorWaliszewska-Prosol, Marta
dc.contributor.authorKoutsokera, Maria
dc.contributor.authorRobotti, Micaela
dc.contributor.authorStraburzynski, Marcin
dc.contributor.authorApostolakopoulou, Loukia
dc.contributor.authorCapizzi, Mariarita
dc.contributor.authorCibuku, Oneda
dc.contributor.authorAmbat, Fidel Dominique Festin
dc.contributor.authorFrattale, Ilaria
dc.contributor.authorGadzhieva, Zukhra
dc.contributor.authorGallo, Erica
dc.contributor.authorGryglas-Dworak, Anna
dc.contributor.authorHalili, Gleni
dc.contributor.authorJusupova, Asel
dc.contributor.authorKoperskaya, Yana
dc.contributor.authorLeheste, Alo-Rainer
dc.contributor.authorManzo, Maria Laura
dc.contributor.authorMarcinno, Andrea
dc.contributor.authorMarino, Antonio
dc.contributor.authorMikulenka, Petr
dc.contributor.authorOng, Bee Eng
dc.contributor.authorPolat, Burcu
dc.contributor.authorPopovic, Zvonimir
dc.contributor.authorRivera-Mancilla, Eduardo
dc.contributor.authorRoceanu, Adina Maria
dc.contributor.authorRollo, Eleonora
dc.contributor.authorRomozzi, Marina
dc.contributor.authorRuscitto, Claudia
dc.contributor.authordi Clemente, Fabrizio Scotto
dc.contributor.authorStrauss, Sebastian
dc.contributor.authorTaranta, Valentina
dc.contributor.authorTerhart, Maria
dc.contributor.authorTychenko, Iryna
dc.contributor.authorVigneri, Simone
dc.contributor.authorMisiak, Blazej
dc.contributor.authorMartelletti, Paolo
dc.contributor.authorRaggi, Alberto
dc.date.accessioned2022-04-15T05:31:31Z
dc.date.available2022-04-15T05:31:31Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractBackground Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are used to reduce the risk of developing Coronavirus Disease 2019 (COVID-19). Despite the significant benefits in terms of reduced risk of hospitalization and death, different adverse events may present after vaccination: among them, headache is one of the most common, but nowadays there is no summary presentation of its incidence and no description of its main features. Methods We searched PubMed and EMBASE covering the period between January 1(st) 2020 and August 6(th), 2021, looking for record in English and with an abstract and using three main search terms (with specific variations): COVID-19/SARS-CoV-2; Vaccination; headache/adverse events. We selected manuscript including information on subjects developing headache after injection, and such information had to be derived from a structured form (i.e. no free reporting). Pooled estimates and 95% confidence intervals were calculated. Analyses were carried out by vaccine vs. placebo, by first vs. second dose, and by mRNA-based vs. "traditional" vaccines; finally, we addressed the impact of age and gender on post-vaccine headache onset. Results Out of 9338 records, 84 papers were included in the review, accounting for 1.57 million participants, 94% of whom received BNT162b2 or ChAdOx1. Headache was generally the third most common AE: it was detected in 22% (95% CI 18-27%) of subjects after the first dose of vaccine and in 29% (95% CI 23-35%) after the second, with an extreme heterogeneity. Those receiving placebo reported headache in 10-12% of cases. No differences were detected across different vaccines or by mRNA-based vs. "traditional" ones. None of the studies reported information on headache features. A lower prevalence of headache after the first injection of BNT162b2 among older participants was shown. Conclusions Our results show that vaccines are associated to a two-fold risk of developing headache within 7 days from injection, and the lack of difference between vaccine types enable to hypothesize that headache is secondary to systemic immunological reaction than to a vaccine-type specific reaction. Some descriptions report onset within the first 24 h and that in around one-third of the cases, headache has migraine-like features with pulsating quality, phono and photophobia; in 40-60% of the cases aggravation with activity is observed. The majority of patients used some medication to treat headache, the one perceived as the most effective being acetylsalicylic acid.
dc.identifier.citationCastaldo, M., Waliszewska-Prosol, M., Koutsokera, M., Robotti, M., Straburzynski, M., Apostolakopoulou, L. ... Raggi, A. (2022). Headache onset after vaccination against SARS-CoV-2: A systematic literature review and meta-analysis. Journal of Headache and Pain, 23(1). https://doi.org/10.1186/s10194-022-01400-4
dc.identifier.doi10.1186/s10194-022-01400-4
dc.identifier.issn1129-2369
dc.identifier.issn1129-2377
dc.identifier.issue1
dc.identifier.pmid35361131
dc.identifier.scopus2-s2.0-85127454576
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s10194-022-01400-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9337
dc.identifier.volume23
dc.identifier.wos000776711600001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorPolat, Burcu
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofJournal of Headache and Painen_US
dc.relation.publicationcategoryDiğer
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectSARS-CoV-2
dc.subjectCOVID-19
dc.subjectVaccination
dc.subjectHeadache
dc.subjectBNT162b2
dc.subjectChAdOx1
dc.subjectHeadache
dc.subjectAdverse Event
dc.titleHeadache onset after vaccination against SARS-CoV-2: A systematic literature review and meta-analysis
dc.typeReview Article

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Polat-Burcu-2022.pdf
Boyut:
991.31 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Diğer Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu