Evaluation of the relationship between vitamin D level and adropin, IL-1?, IL-6, and oxidative status in women

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dc.authorid0000-0002-7675-0014
dc.contributor.authorZorlu, Mehmet
dc.contributor.authorŞekerci, Abdüsselam
dc.contributor.authorTunç, Muhammed
dc.contributor.authorGüler, Eray Metin
dc.contributor.authorGülen, Bedia
dc.contributor.authorKaratoprak, Cumali
dc.contributor.authorKıskaç, Muharrem
dc.contributor.authorÇakırca, Mustafa
dc.date.accessioned2022-09-13T13:05:00Z
dc.date.available2022-09-13T13:05:00Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Ana Bilim Dalı
dc.description.abstractBackground/aim: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. Materials and methods: A total of 77 female subjects were divided into 3 groups according to vitamin D levels. Biochemical parameters, adropin, IL-1ß, IL-6, oxidative stress markers were studied in these groups, and the results were compared statistically. Results: Serum adropin, IL-1ß, IL-6, total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) levels differed significantly between the vitamin D groups (p < 0.05). A significant positive correlation was detected between vitamin D, and adropin and TAS (r = 0.807; p < 0.001, r = 0.814; p < 0.001, respectively). A significant negative correlation was detected between vitamin D, and IL-1ß, IL-6, TOS, OSI (r = –0.725; p < 0.001, r = –0.720; p < 0.001, r = –0.238; p = 0.037, r = –0.705; p < 0.001, respectively). Conclusions: Vitamin D could show its effects through vitamin D receptors on tissues or on the ENHO gene in adropin secreting tissues via direct or indirect mechanisms. Proinflammatory cytokines, oxidative stress, and adropin targeted studies could contribute to the prevention and treatment of diseases associated with vitamin D deficiency in future.
dc.identifier.citationZorlu, M., Şekerci, A., Tunç, M., Güler, E. M., Gülen, B., Karatoprak, C. ... Çakırca, M. (2022). Evaluation of the relationship between vitamin D level and adropin, IL-1?, IL-6, and oxidative status in women. Turkish Journal of Medical Sciences, 52(4), 1197-1206. https://doi.org/10.55730/1300-0144.5424
dc.identifier.doi10.55730/1300-0144.5424
dc.identifier.endpage1206
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4
dc.identifier.pmid36326375
dc.identifier.scopus2-s2.0-85136827766
dc.identifier.scopusqualityQ3
dc.identifier.startpage1197
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5424
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9708
dc.identifier.volume52
dc.identifier.wos000881194200039en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.institutionauthorGülen, Bedia
dc.language.isoen
dc.publisherTurkiye Klinikleri
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectVitamin D
dc.subjectAdropin
dc.subjectIL-1 Beta
dc.subjectIL-6
dc.subjectOxidative Stress
dc.titleEvaluation of the relationship between vitamin D level and adropin, IL-1?, IL-6, and oxidative status in women
dc.title.alternativeEvaluation of the relationship between vitamin D level and adropin, IL-1 beta, IL-6, and oxidative status in women
dc.typeArticle

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