Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model

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dc.authorid0000-0002-1079-8832
dc.authorid0000-0002-0323-6153
dc.authorid0000-0003-4228-4577
dc.authorid0000-0001-9400-187X
dc.authorid0000-0001-6494-8923
dc.contributor.authorOzansoy, Mehmet
dc.contributor.authorAltıntaş, Mehmet Özgen
dc.contributor.authorOzansoy, Muzaffer Beyza
dc.contributor.authorGünay, Necmeddin
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorKılıç, Ülkan
dc.date.accessioned2020-11-12T09:03:28Z
dc.date.available2020-11-12T09:03:28Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractBoron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, cell wall stability in plants, and bone and carbohydrate metabolism in animals. The number of studies about the effect of boron in biological model systems is very limited; so far, there has been no study on the correlation between boron and amyloid-beta toxicity. Here, we investigated the possible effects of 2 boron-containing compounds-sodium borate decahydrate and boric acid-against amyloid-beta toxicity. In our in vitro amyloid-beta toxicity model, we showed that these 2 compounds increase the survival of the SH-SY5Y cells. Furthermore, boron in these 2 forms increases the expression of Sirt1, which has protective functions against cellular stress. The compounds also change the expressions of GSK-3 alpha/beta; by doing so, boron may contribute to the stimulation of intracellular prosurvival pathways. This is the first experimental study indicating the prosurvival effect of boron in an amyloid-beta toxicity model.
dc.identifier.citationOzansoy, M., Altıntaş, M. Ö., Ozansoy, M. B., Günay, N., Kılıç, E. ve Kılıç, Ü. (2020). Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model. Turkish Journal of Biology, 44(4), 208-214. https://dx.doi.org/10.3906/biy-2001-22
dc.identifier.doi10.3906/biy-2001-22
dc.identifier.endpage214
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage208
dc.identifier.urihttps://dx.doi.org/10.3906/biy-2001-22
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6019
dc.identifier.volume44
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherScientific and Technological Research Council of Turkey (TÜBİTAK)
dc.relation.ispartofTurkish Journal of Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectBoron
dc.subjectNeuronal Survival
dc.subjectAmyloid-Beta
dc.subjectSirt1
dc.subjectGSK-3 Alpha/Beta
dc.titleTwo boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model
dc.typeArticle

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