Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats

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dc.authorid0000-0003-0804-1475
dc.contributor.authorAlev Tüzüner, Burçin
dc.contributor.authorTunalı, Sevim
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorİpekçi, Hazal
dc.contributor.authorEmekli Alturfan, Ebru
dc.contributor.authorTunalı Akbay, Tuğba
dc.contributor.authorYanardağ, Refiye
dc.contributor.authorYarat, Ayşen
dc.date.accessioned2023-06-13T07:13:16Z
dc.date.available2023-06-13T07:13:16Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractValproic acid, one of the most used drugs for epilepsy patients, has some known side effects. Chard extract has many pharmacological activities. The study aims to evaluate whether valproic acid might interfere with oxidative metabolism in gastric tissue and whether chard ameliorates these effects. The Sprague Dawley rats were divided into four groups (n=8); control, chard-given control, valproic acid, and chard-given valproic acid. The aqueous extracts of chard leaves were given 1 h before the administration of valproic acid for 7 days. On the 8th day, the animals were sacrificed under anesthesia and gastric tissues were homogenized. When compared to the control group, valproic acid significantly increased malondialdehyde and catalase activity, while superoxide dis- mutase activity decreased. Chard administration increased glutathione and, sialic acid levels and decreased malondialdehyde levels and superoxide dismutase activity in the valproic acid group. Based on these findings, since chard increased gastric sialic acid levels, we may suggest that chard may protect gastric mucosa may be through its antioxidant effects.
dc.identifier.citationAlev Tüzüner, B., Tunalı, S., Üstündağ, Ü. V., İpekçi, H., Emekli Alturfan, E., Tunalı Akbay, T. ... Yarat, A. (2023). Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats. Food and Health, 9(2), 139-147. https://doi.org/10.3390/nu14091933
dc.identifier.doi10.3390/nu14091933
dc.identifier.endpage147
dc.identifier.issn2602-2834
dc.identifier.issue2
dc.identifier.startpage139
dc.identifier.trdizinid1165593
dc.identifier.urihttps://doi.org/10.3390/nu14091933
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11073
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorÜstündağ, Ünsal Veli
dc.language.isoen
dc.publisherScientificWebJournals (SWJ) Özkan Özden
dc.relation.ispartofFood and Healthen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectGastric Tissue
dc.subjectValproic Acid
dc.subjectChard
dc.subjectSialic Acid
dc.subjectOxidative Stress
dc.titleChard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats
dc.typeArticle

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