Energy drink induced lipid peroxidation and oxidative damage in rat liver and brain when used alone or combined with alcohol

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dc.authorid0000-0002-5532-2395
dc.contributor.authorReis, Rengin
dc.contributor.authorCharehsaz, Mohammad
dc.contributor.authorSipahi, Hande
dc.contributor.authorDoğan Ekici, Asiye Işın
dc.contributor.authorMacit, Çağlar
dc.contributor.authorAkkaya, Hatice
dc.contributor.authorAydın, Ahmet
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:08Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:08Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalı
dc.descriptionWOS: 000400813600024
dc.descriptionPubMed ID: 28304088
dc.description.abstractEnergy drinks (ED) are containing large doses of metabolic stimulants and its use with ethanol has increased dramatically among young adults. In this study, we examined the effects of ED exposure either alone or in combination with ethanol on oxidative stress parameters including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and lipid peroxidation parameter malondialdehyde (MDA) in rat. Some histopathological findings were also evaluated. ED exposure led to a dose-dependent increase in liver MDA compared to the control indicating oxidative damage. Histopathological findings also revealed that ED alone may generate liver damage. Ethanol exposure increased MDA level and SOD, CAT, and GSH-Px activity in both the brain and the liver. The combination of ethanol and ED produced greater damage which is considered by further increases in SOD and GSH-Px activity in the brain. Similar results for MDA were observed in both the liver and brain as well. Our findings suggest that ED consumption alone or combination with ethanol may represent a significant public health concern.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [2209A]en_US
dc.description.sponsorshipThis project was supported by the Scientific and Technological Research Council of Turkey (TUBITAK), 2209A.en_US
dc.identifier.citationReis, R., Charehsaz, M., Sipahi, H., Doğan Ekici, A. I., Macit, Ç., Akaya, H. ... Aydın, A. (2017). Energy drink induced lipid peroxidation and oxidative damage in rat liver and brain when used alone or combined with alcohol. Journal of Food Science, 82(4), 1037-1043. https://dx.doi.org/10.1111/1750-3841.13662
dc.identifier.doi10.1111/1750-3841.13662
dc.identifier.endpage1043
dc.identifier.issn0022-1147
dc.identifier.issn1750-3841
dc.identifier.issue4
dc.identifier.scopusqualityQ1
dc.identifier.startpage1037
dc.identifier.urihttps://dx.doi.org/10.1111/1750-3841.13662
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3114
dc.identifier.volume82
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Food Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlcohol
dc.subjectEnergy Drink
dc.subjectEthanol and Energy Drink Mixture
dc.subjectLipid Peroxidation
dc.subjectOxidative Dtress
dc.titleEnergy drink induced lipid peroxidation and oxidative damage in rat liver and brain when used alone or combined with alcohol
dc.typeArticle

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