Effects of varicocele repair on sperm dna fragmentation and seminal malondialdehyde levels in infertile men with clinical varicocele a systematic review and meta-analysis

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dc.authorid0000-0001-7933-4262
dc.authorid0000-0002-9976-9666
dc.authorid0000-0002-6308-1763
dc.contributor.authorCannarella, Rossella
dc.contributor.authorShah, Rupin
dc.contributor.authorSaleh, Ramadan
dc.contributor.authorBoitrelle, Florence
dc.contributor.authorHamoda, Taha Abo-Almagd Abdel-Meguid
dc.contributor.authorSingh, Rajender
dc.contributor.authorSalvio, Gianmaria
dc.contributor.authorToprak, Tuncay
dc.contributor.authorFalcone, Marco
dc.contributor.authorGül, Murat
dc.contributor.authorDimitriadis, Fotios
dc.contributor.authorRambhatla, Amarnath
dc.contributor.authorRusso, Giorgio I.
dc.contributor.authorKo, Edmund
dc.contributor.authorZini, Armand
dc.contributor.authorKavoussi, Parviz
dc.contributor.authorPhuoc, Nguyen Ho Vinh
dc.contributor.authorKandil, Hussein
dc.contributor.authorGhayda, Ramy Abou
dc.contributor.authorBirowo, Ponco
dc.contributor.authorGherabi, Nazim
dc.contributor.authorCeyhan, Erman
dc.contributor.authorDong, Jie
dc.contributor.authorMalhotra, Vineet
dc.contributor.authorDurairajanayagam, Damayanthi
dc.contributor.authorKolbaşı, Bircan
dc.contributor.authorBahar, Fahmi
dc.contributor.authorÇalık, Gökhan
dc.contributor.authorÇayan, Selahittin
dc.contributor.authorPinggera, Germar Michael
dc.contributor.authorCalogero, Aldo E.
dc.contributor.authorRajmil, Osvaldo
dc.contributor.authorMostafa, Taymour
dc.contributor.authorAtmoko, Widi
dc.contributor.authorHarraz, Ahmed M.
dc.contributor.authorLe, Tan V.
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.contributor.authorHakim, Lukman
dc.contributor.authorPescatori, Edoardo
dc.contributor.authorSergeyev, Oleg
dc.contributor.authorRashed, Ayman
dc.contributor.authorSaini, Pallavi
dc.contributor.authorAgarwal, Ashok
dc.date.accessioned2024-05-15T07:45:11Z
dc.date.available2024-05-15T07:45:11Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractPurpose: Varicoceles can be a source of elevated seminal oxidative stress (OS) and sperm DNA fragmentation (SDF). How­ever, it remains unclear whether varicocele repair (VR) could reduce these parameters. This systematic review and meta-analysis (SRMA) aims to investigate the impact of VR on SDF and seminal malondialdehyde (MDA). Materials and Methods: A literature search was performed in Scopus, PubMed, Ovid, Embase, and Cochrane databases. This SRMA included randomized controlled trials and observational studies reporting the pre- and postoperative levels of SDF and seminal OS in infertile men with clinical varicocele that underwent VR. Subgroup analyses included techniques of VR and SDF testing. The effect size was expressed as standardized mean difference (SMD). Results: Out of 1,632 abstracts assessed for eligibility, 29 studies with 1,491 infertile men were included. The analysis showed a significant reduction in SDF after VR, compared to preoperative values (SMD -1.125, 95% confidence interval [CI] -1.410, -0.840; p<0.0001) with high inter-study heterogeneity (I2=90.965%). Reduction in SDF was evident with microsurgical technique and non-microsurgical inguinal approaches (SMD -1.014, 95% CI -1.263, -0.765; p<0.0001, and SMD -1.495, 95% CI -2.116, -0.873; p<0.0001), respectively. Reduction in SDF was significant irrespective of testing was done by sperm chromatin dispersion (SMD -2.197, 95% CI -3.187, -1.207; p<0.0001), sperm chromatin structure assay (SMD -0.857, 95% CI -1.156, -0.559; p<0.0001) or TUNEL (SMD -1.599, 95% CI -2.478, -0.719; p<0.0001). A significant decrease in seminal MDA levels was observed following VR (SMD -2.450, 95% CI -3.903 to -0.997, p=0.001) with high inter-study heterogene­ity (I2=93.7%). Conclusions: Using pre- and post-intervention data, this SRMA indicates a significant reduction in SDF and seminal MDA levels in infertile men with clinical varicocele treated with VR. These findings may have important implications for the future management of this selected group of infertile patients.
dc.identifier.citationCannarella, R., Shah, R., Saleh, R., Boitrelle, F., Hamoda, T. A. A. A. M., Singh, R. ... Agarwal, A. (2024). Effects of varicocele repair on sperm dna fragmentation and seminal malondialdehyde levels in infertile men with clinical varicocele a systematic review and meta-analysis. World Journal of Men's Health, 42(2), 321-337. http://dx.doi.org/10.5534/wjmh.230235
dc.identifier.doi10.5534/wjmh.230235
dc.identifier.endpage337
dc.identifier.issn2287-4208
dc.identifier.issn2287-4690
dc.identifier.issue2
dc.identifier.pmid38164034
dc.identifier.scopus2-s2.0-85189533509
dc.identifier.scopusqualityQ1
dc.identifier.startpage321
dc.identifier.urihttp://dx.doi.org/10.5534/wjmh.230235
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12456
dc.identifier.volume42
dc.identifier.wos001133097100001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKolbaşı, Bircan
dc.institutionauthorÇalık, Gökhan
dc.institutionauthorde la Rosette, Jean J. M. C. H.
dc.language.isoen
dc.relation.ispartofWorld Journal of Men's Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDNA Fragmentation
dc.subjectInfertility
dc.subjectMale
dc.subjectMalondialdehyde
dc.subjectVaricocele
dc.titleEffects of varicocele repair on sperm dna fragmentation and seminal malondialdehyde levels in infertile men with clinical varicocele a systematic review and meta-analysis
dc.typeOther

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