Impact of fatty liver on hepatitis B virus replication and virologic response to tenofovir and entecavir

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dc.authorid0000-0001-9658-7560
dc.authorid0000-0001-8554-7651
dc.authorid0000-0001-8022-7325
dc.authorid0000-0001-8945-2385
dc.contributor.authorCeylan, Bahadır
dc.contributor.authorArslan, Ferhat
dc.contributor.authorBatırel, Ayşe
dc.contributor.authorFincancı, Muzaffer
dc.contributor.authorYardımcı, Cem
dc.contributor.authorFersan, Esra
dc.contributor.authorPaşaoğlu, Esra
dc.contributor.authorYılmaz, Mesut
dc.contributor.authorMert, Ali
dc.date.accessioned08.07.201910:49:13
dc.date.accessioned2019-07-08T20:18:47Z
dc.date.available08.07.201910:49:13
dc.date.available2019-07-08T20:18:47Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractBackground/Aims: We aimed to evaluate the impact of non-alcoholic fatty liver disease (NAFLD) on viral kinetics and virologic response to tenofovir and entecavir treatment in patients with chronic hepatitis B virus (HBV) infection.Materials and Methods: This study was designed as a retrospective multicenter cohort study. The impact of hepatosteatosis on pre-treatment serum HBV DNA levels and also on the virologic response to either tenofovir or entecavir at 6 and 12 months of therapy was investigated. Results: A total of 145 cases were involved in the study [median age 40 (18-73) years, 90 (62%) males]. In multivariate analysis, it was detected that patients with NAFLD were older and had a higher body mass index (BMI) [Odds ratio (95% confidence interval) and p-value for age were 1.040 (1.003-1.079) and 0.033 and for BMI were 1.348 (1.190-1.528) and 0.0001, respectively]. When only the 43 patients who were younger than 35.5 years old and who had a BMI less than 27.59 were investigated, serum high-density lipoprotein (HDL) levels and serum HBV DNA levels were lower in patients with NAFLD in multivariate analysis [Odds ratio (95% confidence interval) and p-values for serum HDL level and HBV DNA level were 0.864 (0.061-0.980) and 0.023 and 0.995 (0.990-0.999) and 0.025, respectively]. Totally, 57 and 75 of the patients had received entecavir and tenofovir, respectively. Conclusion: Viral replication decreases in patients with chronic HBV infection in the presence of NAFLD, and NAFLD had no impact on the virologic response to entecavir and tenofovir treatment
dc.identifier.citationCeylan, B., Arslan, F., Batırel, A., Fincancı, M., Yardımcı, C., Fersan, E. ... Mert, A. (2016). Impact of fatty liver on hepatitis B virus replication and virologic response to tenofovir and entecavir. Turkish Journal of Gastroenterology, 27(1), 42-46. https://dx.doi.org/10.5152/tjg.2015.150348
dc.identifier.endpage46
dc.identifier.issn1300-4948
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage42
dc.identifier.urihttps://hdl.handle.net/20.500.12511/482
dc.identifier.urihttps://dx.doi.org/10.5152/tjg.2015.150348
dc.identifier.volume27
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEntecavir
dc.subjectFatty Liver
dc.subjectHepatitis B Virus
dc.titleImpact of fatty liver on hepatitis B virus replication and virologic response to tenofovir and entecavir
dc.typeArticle

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