A retrospective evaluation of the epithelial changes/lesions and neoplasms of the Gallbladder in Turkey and a review of the existing sampling methods: A multicentre study

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dc.authorid0000-0001-6830-7701
dc.contributor.authorEsendağlı, Güldal
dc.contributor.authorAkarca, Fahire Göknur
dc.contributor.authorBalcı, Serdar
dc.contributor.authorArgon, Asuman
dc.contributor.authorŞengiz Erhan, Selma
dc.contributor.authorTurhan, Nesrin
dc.contributor.authorİnce Zengin, Neslihan
dc.contributor.authorHallaç Keser, Sevinç
dc.contributor.authorÇelik, Betül
dc.contributor.authorBulut, Tangül
dc.contributor.authorAbdullazade, Samir
dc.contributor.authorErden, Esra
dc.contributor.authorSavaş, Berna
dc.contributor.authorBostan, Temmuz
dc.contributor.authorSağol, Özgül
dc.contributor.authorAysal Ağalar, Anıl
dc.contributor.authorKepil, Nuray
dc.contributor.authorKarslıoğlu, Yıldırım
dc.contributor.authorGünal, Armağan
dc.contributor.authorMarkoç, Fatma
dc.contributor.authorSaka, Burcu
dc.contributor.authorÖzgün, Gonca
dc.contributor.authorÖzdamar, Şükrü Oğuz
dc.contributor.authorBahadır, Burak
dc.contributor.authorKaymaz, Esin
dc.contributor.authorIşık, Emre
dc.contributor.authorAyhan, Semin
dc.contributor.authorTuncel, Deniz
dc.contributor.authorÖzgüven Yılmaz, Banu
dc.contributor.authorÇelik, Sevinç
dc.contributor.authorKarabacak, Tuba
dc.contributor.authorErbarut Seven, İpek
dc.contributor.authorAtaizi Çelikel, Çiğdem
dc.contributor.authorGücin, Zuhal
dc.contributor.authorEkinci, Özgür
dc.contributor.authorAkyol, Gülen
dc.date.accessioned2021-01-18T06:32:06Z
dc.date.available2021-01-18T06:32:06Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractObjective: As there is continuing disagreement among the observers on the differential diagnosis between the epithelial changes/lesions and neoplasms of the gallbladder, this multicentre study was planned in order to assess the rate of the epithelial gallbladder lesions in Turkey and to propose microscopy and macroscopy protocols. Material and Method: With the participation of 22 institutions around Turkey that were included in the Hepato-Pancreato-Biliary Study Group, 89,324 cholecystectomy specimens sampled from 2003 to 2016 were retrospectively evaluated. The numbers of adenocarcinomas, dysplasias, intracholecystic neoplasms/adenomas, intestinal metaplasias and reactive atypia were identified with the review of pathology reports and the regional and countrywide incidence rates were presented in percentages. Results: Epithelial changes/lesions were reported in 6% of cholecystectomy materials. Of these epithelial lesions, 7% were reported as adenocarcinoma, 0.9% as high-grade dysplasia, 4% as low-grade dysplasia, 7.8% as reactive/regenerative atypia, 1.7% as neoplastic polyp, and 15.6% as intestinal metaplasia. The remaining lesions (63%) primarily included non-neoplastic polypoids/hyperplastic lesions and antral/pyloric metaplasia. There were also differences between pathology laboratories. Conclusion: The major causes of the difference in reporting these epithelial changes/lesions and neoplasms include the differences related to the institute’s oncological surgery frequency, sampling protocols, geographical dissimilarities, and differences in the diagnoses/interpretations of the pathologists. It seems that the diagnosis may change if new sections are taken from the specimen when any epithelial abnormality is seen during microscopic examination of the cholecystectomy materials.
dc.identifier.citationEsendağlı, G., Akarca, F. G., Balcı, S., Argon, A., Şengiz Erhan, S., Turhan, N. ... Akyol, G. (2018). A retrospective evaluation of the epithelial changes/lesions and neoplasms of the Gallbladder in Turkey and a review of the existing sampling methods: A multicentre study. Turkish Journal of Pathology, 34(1), 41-48. https://dx.doi.org/10.5146/tjpath.2017.01404
dc.identifier.doi10.5146/tjpath.2017.01404
dc.identifier.endpage48
dc.identifier.issn1018-5615
dc.identifier.issn1309-5730
dc.identifier.issue1
dc.identifier.scopusqualityN/A
dc.identifier.startpage41
dc.identifier.urihttps://dx.doi.org/10.5146/tjpath.2017.01404
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6266
dc.identifier.volume34
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFederation of Turkish Pathology Societies
dc.relation.ispartofTurkish Journal of Pathologyen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGallbladder
dc.subjectCholecystectomy
dc.subjectDysplasia
dc.subjectNeoplasia
dc.subjectSampling
dc.titleA retrospective evaluation of the epithelial changes/lesions and neoplasms of the Gallbladder in Turkey and a review of the existing sampling methods: A multicentre study
dc.typeReview Article

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