Blood viscosity and inflammatory indices in treatment-resistant schizophrenia: A retrospective cross-sectional study

Balcıoğlu, Yasin Hasan; Gökçay, Hasan; Yeşilkaya, Ümit Haluk; Kirlioğlu Balcıoğlu, Simge Seren

Blood viscosity and inflammatory indices in treatment-resistant schizophrenia: A retrospective cross-sectional study

dc.authorid	0000-0001-8521-1613
dc.contributor.author	Balcıoğlu, Yasin Hasan
dc.contributor.author	Gökçay, Hasan
dc.contributor.author	Yeşilkaya, Ümit Haluk
dc.contributor.author	Kirlioğlu Balcıoğlu, Simge Seren
dc.date.accessioned	2023-07-13T09:00:11Z
dc.date.available	2023-07-13T09:00:11Z
dc.date.issued	2023
dc.department	İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.department	İstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.description.abstract	Objective: Alterations in blood flow and inflammation may be associated with the treatment response of psychotic disorders. However, changes in blood viscosity in patients with treatment-resistant schizophrenia (TRS) have yet to be studied. We examined whether blood viscosity and systemic inflammatory status varied between patients with TRS, remitted schizophrenia, and healthy subjects.Method: Forty patients with TRS, 40 remitted schizophrenia patients, and 43 age- and gender-matched healthy controls were enrolled in this retrospective file review study. Whole blood viscosity (WBV) was calculated according to de Simone's formula at low and high shear rates (LSR and HSR, respectively). Complete blood count (CBC) markers of inflammation were recorded through screening data at admission.Results: In patients with TRS, WBV at both LSR and HSR was significantly decreased, whereas all CBC markers of inflammation were significantly increased compared to controls. Remitted patients had significantly decreased WBV at HSR than controls. There was no significant correlation between blood viscosity and CBC markers in patients. According to the regression models, the systemic immune-inflammation index (& beta;=0.578) and monocyte-to-lymphocyte ratio (& beta;=1.844) were significantly associated with WBV at LSR in multivariate analyses, whereas the Positive and Negative Syndrome Scale (PANSS) Positive subscale (& beta;=-0.330) was significantly associated with WBV at HSR in univariate analyses in the patient sample.Conclusion: TRS, associated with decreased blood viscosity and increased inflammatory status, may not fully explain such a reflect the pathophysiological process underlying treatment responsiveness as well as cardiovascular morbidity.
dc.identifier.citation	Balcıoğlu, Y. H., Gökçay, H., Yeşilkaya, Ü. H. ve Kirlioğlu Balcıoğlu, S. S. (2023). Blood viscosity and inflammatory indices in treatment-resistant schizophrenia: A retrospective cross-sectional study. Journal of Psychiatry and Neurological Sciences, 36(2), 81-89. https://dx.doi.org/10.14744/DAJPNS.2023.00210
dc.identifier.doi	10.14744/DAJPNS.2023.00210
dc.identifier.endpage	89
dc.identifier.issn	1018-8681
dc.identifier.issn	1309-5749
dc.identifier.issue	2
dc.identifier.startpage	81
dc.identifier.trdizinid	1183403
dc.identifier.uri	https://dx.doi.org/10.14744/DAJPNS.2023.00210
dc.identifier.uri	https://hdl.handle.net/20.500.12511/11192
dc.identifier.volume	36
dc.identifier.wos	001012089900004	en_US
dc.identifier.wosquality	N/A
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	TR-Dizin
dc.institutionauthor	Yeşilkaya, Ümit Haluk
dc.language.iso	en
dc.publisher	Kare Publishing
dc.relation.ispartof	Journal of Psychiatry and Neurological Sciences	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Antipsychotics
dc.subject	Blood Viscosity
dc.subject	Cardiovascular Risk
dc.subject	Inflammation
dc.subject	Psychosis
dc.title	Blood viscosity and inflammatory indices in treatment-resistant schizophrenia: A retrospective cross-sectional study
dc.type	Article